Evidence map›Paper›PMID 35219757›Full record

ArticlePharmacology, biochemistry, and behavior2022

Sex and social status modify the effects of fluoxetine on socioemotional behaviors in Syrian hamsters and rhesus macaques.

Dené A Voisin, Alison Wakeford, Jonathon Nye, Jiyoung Mun, Sara R Jones, Jason Locke, Kim L Huhman, Mark E Wilson, H Elliott Albers, Vasiliki Michopoulos

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Alterations in adolescent brain serotonin (5HT)Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Dené A VoisinNeuroscience Institute, Georgia State University, Atlanta, GA, United States of America; Center for Behavioral Neuroscience, Atlanta, GA, United States of America.
Alison WakefordYerkes National Primate Research Center, Atlanta, GA, United States of America.
Jonathon NyeYerkes National Primate Research Center, Atlanta, GA, United States of America; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States of America.
Jiyoung MunYerkes National Primate Research Center, Atlanta, GA, United States of America; Molecular Imaging Department, Charles River Laboratories, Mattawan, MI, United States of America.
Sara R JonesDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Jason LockeDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Kim L HuhmanNeuroscience Institute, Georgia State University, Atlanta, GA, United States of America; Center for Behavioral Neuroscience, Atlanta, GA, United States of America.
Mark E WilsonYerkes National Primate Research Center, Atlanta, GA, United States of America; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States of America.
H Elliott AlbersNeuroscience Institute, Georgia State University, Atlanta, GA, United States of America; Center for Behavioral Neuroscience, Atlanta, GA, United States of America.
Vasiliki MichopoulosYerkes National Primate Research Center, Atlanta, GA, United States of America; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States of America. Electronic address: vmichop@emory.edu.
Emory National Primate Research CenterGeorgia State University · USWake Forest University · USCenter for Neurosciences · USCharles River Laboratories (United States) · USEmory University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Sex Differences in the Social BrainR01MH110212 · NIMH · GEORGIA STATE UNIVERSITY · PI ALBERS, H. ELLIOTT, MICHOPOULOS, VASILIKI · 2016 to 2020
$3.3M
Sex-dependent regulation of social reward by oxytocin in the mesolimbic reward circuitryR01MH122622 · NIMH · GEORGIA STATE UNIVERSITY · PI ALBERS, H. ELLIOTT, HUHMAN, KIM L · 2021 to 2025
$2.7M
NIH HHS P51 OD011132NIMH NIH HHS R01 MH110212NIMH NIH HHS R01 MH122622
6 · The paper itself

Abstract

Social subordination increases risk for psychiatric disorders, while dominance increases resilience to these disorders. Fluoxetine, a selective serotonin (5HT) reuptake inhibitor whose actions are mediated in part by the 5HT1A receptor (5HT1AR), has sex- and social status-specific effects on socioemotional behavior and aggressive behavior. However, the impact of social status on these sex-specific effects remains unclear. The current study evaluated the impact of acute fluoxetine treatment and social status on dominance-related behaviors in female and male hamsters, and the impact of chronic fluoxetine treatment on socioemotional behavior and 5HT1AR binding potential (5HT1AR

Indexed as

FluoxetineSocial StatusAggressionAnimalsCricetinaeFemaleHumansMacaca mulattaMaleMesocricetusFluoxetineAggressionFluoxetineHamstersMonkeysSerotoninSex differencesSocial dominance

Identifiers

PMID35219757
PMCPMC8983589
OpenAlexW4213441855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.