Evidence map›Paper›PMID 35218721›Full record

ArticleArchives of biochemistry and biophysics2022

A short HLA-DRA isoform binds the HLA-DR2 heterodimer on the outer domain of the peptide-binding site.

Hengameh Shams, Jill A Hollenbach, Atsuko Matsunaga, Mohammad R K Mofrad, Jorge R Oksenberg, Alessandro Didonna

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hengameh ShamsWeill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, 94158, USA.
Jill A HollenbachWeill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, 94158, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, 94158, USA.
Atsuko MatsunagaWeill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, 94158, USA.
Mohammad R K MofradDepartments of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA, 94720, USA.
Jorge R OksenbergWeill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, 94158, USA.
Alessandro DidonnaWeill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, 94158, USA; Department of Anatomy and Cell Biology, East Carolina University, Greenville, NC, 27834, USA. Electronic address: didonnaal21@ecu.edu.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

NRSA Training CoreTL1TR001871 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SOMSOUK, MA · 2016 to 2025
$10.1M
P0531582 Oksenberg/Hollenbach R01NS102153 SupplementR01NS102153 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLENBACH, JILL ALLISON, OKSENBERG, JORGE R. · 2017 to 2021
$3.6M
NCATS NIH HHS TL1 TR001871NINDS NIH HHS R01 NS102153
6 · The paper itself

Abstract

The human leukocyte antigen (HLA) locus encodes a large group of proteins governing adaptive and innate immune responses. Among them, HLA class II proteins form α/β heterodimers on the membrane of professional antigen-presenting cells (APCs), where they display both, self and pathogen-derived exogenous antigens to CD4

Indexed as

HLA-DR2 AntigenPeptidesBinding SitesHLA-DR alpha-ChainsHumansProtein IsoformsHLA-DR2 AntigenHLA-DR alpha-ChainsPeptidesProtein IsoformsAntigen presentationMolecular dynamicsProtein-protein bindingStructural modulation

Identifiers

PMID35218721
PMCPMC9007275
OpenAlexW4213449217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.