Evidence map›Paper›PMID 35218469›Full record

ArticleCardiovascular drugs and therapy2023

Effect of Insulin Resistance on Recurrence after Radiofrequency Catheter Ablation in Patients with Atrial Fibrillation.

Zhe Wang, Yi-Jia Wang, Zhi-Yu Liu, Qing Li, Ya-Wei Kong, Ying-Wei Chen, Yi-Hong Sun, Jian-Zeng Dong

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Cardiovascular drugs and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Zhe WangGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Yi-Jia WangGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Zhi-Yu LiuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan, China.
Qing LiDepartment of Cardiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, 100029, China.
Ya-Wei KongDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan, China.
Ying-Wei ChenDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan, China. zzyingweichen@126.com.ORCID http://orcid.org/0000-0003-0078-8304
Yi-Hong SunDepartment of Cardiology, China-Japan Friendship Hospital, No.2 East Yinghua Road, Beijing, 100029, Chaoyang District, China. yihongsun72@163.com.
Jian-Zeng DongDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan, China.
First Affiliated Hospital of Zhengzhou University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNCapital Medical University · CNChina-Japan Friendship Hospital · CNPeking University · CN

Funding

National Key Research and Development Program 2016YFC1301000
6 · The paper itself

Abstract

backgroundWhether there are many risk factors for recurrence of atrial fibrillation (AF) after ablation is unclear. The aim of this study was to investigate the relationship between insulin resistance (IR) and AF recurrence in patients without diabetes who underwent catheter ablation.

methodsThis retrospective study included patients who underwent AF ablation between 2018 and 2019 at the First Affiliated Hospital of Zhengzhou University. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated, and a value of ≥2.69 was defined as IR. The patients were divided into two groups (group 1 HOMA-IR < 2.69, n = 163; group 2 HOMA-IR ≥ 2.69, n = 69). AF recurrence was defined as the occurrence of atrial arrhythmias of more than 30 s after the first 3 months. Univariate and multivariable Cox regression models were used to analyse the risk of AF recurrence.

resultsOverall, 232 patients were enrolled (mean age, 59.9 ± 10.2 years old; female, 37.5%; paroxysmal AF, 71.6%). We found that dyslipidaemia, antiarrhythmic drug use, fasting blood glucose and fasting insulin were significantly higher in the IR group (P < 0.05). During the follow-up 1 year after ablation, 62 (26.7%) patients experienced AF recurrence. After adjusting for traditional risk factors, multivariable analysis showed that the HOMA-IR value (HR 1.259, 95% CI 1.086-1.460, P = 0.002) and left atrial diameter (LAD; HR 1.043, 95% CI 1.005-1.083, P = 0.026) were independently associated with AF recurrence.

conclusionsThe present results provide evidence that IR patients are more likely to experience AF recurrence. Improving IR status may be a potential target for reducing the postoperative recurrence rate.

Indexed as

Atrial FibrillationCatheter AblationInsulin ResistanceAgedFemaleHumansMiddle AgedRetrospective StudiesRisk FactorsTreatment OutcomeAtrial fibrillationInsulin resistanceRadiofrequency ablationRecurrence

Identifiers

PMID35218469
OpenAlexW4220743506

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.