Evidence map›Paper›PMID 35218459›Full record

ArticleJournal of natural medicines2022

Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum in olfactory bulbectomized mice.

Hien Thu Nguyen, Xoan Thi Le, Tai Van Nguyen, Hoa Nhu Phung, Hang Thi Nguyet Pham, Khoi Minh Nguyen, Kinzo Matsumoto

Abstract read
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Article in Journal of natural medicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Hien Thu NguyenDepartment of Pharmacology and Biochemistry, National Institute of Medicinal Materials, Hanoi, 10000, Vietnam.
Xoan Thi LeDepartment of Pharmacology and Biochemistry, National Institute of Medicinal Materials, Hanoi, 10000, Vietnam. xoanle@nimm.org.vn.ORCID http://orcid.org/0000-0002-4471-3155
Tai Van NguyenDepartment of Phytochemistry, National Institute of Medicinal Materials, Hanoi, 10000, Vietnam.
Hoa Nhu PhungDepartment of Phytochemistry, National Institute of Medicinal Materials, Hanoi, 10000, Vietnam.
Hang Thi Nguyet PhamDepartment of Pharmacology and Biochemistry, National Institute of Medicinal Materials, Hanoi, 10000, Vietnam.
Khoi Minh NguyenDepartment of Phytochemistry, National Institute of Medicinal Materials, Hanoi, 10000, Vietnam.
Kinzo MatsumotoGraduate School of Pharmaceutical Sciences, Daiichi University of Pharmacy, Fukuoka, 815-8511, Japan.
National Institute of Nutrition · VNDaiichi University of Pharmacy · JP

Funding

National Foundation for Science and Technology Development 106-YS.05-2016.22
6 · The paper itself

Abstract

This study aims to clarify the bioactive constituents responsible for the anti-dementia effects of Ocimum sanctum Linn. ethanolic extract (OS) using olfactory bulbectomized (OBX) mice, an animal model of dementia. The effects of OS or its extract further fractionated with n-hexane (OS-H), ethyl acetate (OS-E), and n-butanol (OS-B) on the spatial cognitive deficits of OBX mice were elucidated by the modified Y-maze tests. The effects of the major constituents of the most active OS fraction were also elucidated using the reference drug donepezil. The administration of OS and OS-E ameliorated the spatial cognitive deficits caused by OBX, whereas OS-H or OS-B had no effect. Two major constituents, ursolic acid (URO) and oleanolic acid (OLE), and three minor constituents were isolated from OS-E. URO (6 and 12 mg/kg) and OLE (24 mg/kg) attenuated the OBX-induced cognitive deficits. URO (6 mg/kg) and donepezil reversed the OBX-induced down-regulation of vascular endothelial growth factor (VEGF) and choline acetyltransferase expression levels in the hippocampus. URO inhibited the ex vivo activity of acetylcholinesterase with similar efficacy to donepezil. URO inhibited the in vitro activity of acetylcholinesterase (IC

Indexed as

Ocimum sanctumOleanolic AcidAcetylcholinesteraseAnimalsDonepezilMiceOlfactory BulbPlant ExtractsTriterpenesUrsolic AcidVascular Endothelial Growth Factor AAcetylcholinesteraseDonepezilOleanolic AcidPlant ExtractsTriterpenesUrsolic AcidVascular Endothelial Growth Factor ACholinergic systemCognitive dysfunctionOcimum sanctumOleanolic acidUrsolic acidVEGF

Identifiers

PMID35218459
OpenAlexW4214751369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.