ArticleIntensive care medicine2022
Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19.
Article in Intensive care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Comparative analysis of COVID-19 critically ill patients across four pandemic waves in Greece.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Multiplex Targeted Proteomic Analysis of Cytokine Ratios for ICU Mortality in Severe COVID-19.Proteomes · 2025Article
- Cardiovascular Outcomes in Hospitalized Patients with COVID-19: Does Age Really Matter?Journal of cardiovascular development and disease · 2025Article
- Exploring the Association of Metabolic Syndrome with In-Hospital Survival of Older Patients Hospitalized with COVID-19: Beyond Chronological Age.Journal of general internal medicine · 2024Article
- Caring for frail patients in the ICU: a multidimensional approach.Intensive care medicine · 2024Article
- Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia.Tropical medicine and infectious disease · 2024Article
- Observational
- Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic.Annals of intensive care · 2023Article
- Nationwide analysis of hospital admissions and outcomes of patients with SARS-CoV-2 infection in Austria in 2020 and 2021.Scientific reports · 2023Article
- The positive impact of COVID-19 on critical care: from unprecedented challenges to transformative changes, from the perspective of young intensivists.Annals of intensive care · 2023Review
- Limitation of life-sustaining therapies in critically ill patients with COVID-19: a descriptive epidemiological investigation from the COVID-ICU study.Critical care (London, England) · 2023Article
- Authors` response to "Efficacy of noninvasive ventilation in patients with COVID-19".Critical care (London, England) · 2022Article
- Clustering analysis of geriatric and acute characteristics in a cohort of very old patients on admission to ICU.Intensive care medicine · 2022Article
- Specialist Palliative Care Consultations in COVID-19 Patients in the ICU-A Retrospective Analysis of Patient Characteristics and Symptoms at a German University Hospital.Journal of clinical medicine · 2022Article
- Impact of frailty on clinical outcomes in patients with and without COVID-19 pneumonitis admitted to intensive care units in Australia and New Zealand: a retrospective registry data analysis.Critical care (London, England) · 2022Article
- External Validation of Mortality Scores among High-Risk COVID-19 Patients: A Romanian Retrospective Study in the First Pandemic Year.Journal of clinical medicine · 2022Article
- Risk Factors and Mortality in Elderly ARDS COVID-19 Compared to Patients without COVID-19.Journal of clinical medicine · 2022Article
- Palliative care practice and moral distress during COVID-19 pandemic (PEOpLE-C19 study): a national, cross-sectional study in intensive care units in the Czech Republic.Critical care (London, England) · 2022Observational
Corrections and comments
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Authors and funding
22 authors at 19 institutions in 16 countries.
Funding
Abstract
purposeThe number of patients ≥ 80 years admitted into critical care is increasing. Coronavirus disease 2019 (COVID-19) added another challenge for clinical decisions for both admission and limitation of life-sustaining treatments (LLST). We aimed to compare the characteristics and mortality of very old critically ill patients with or without COVID-19 with a focus on LLST.
methodsPatients 80 years or older with acute respiratory failure were recruited from the VIP2 and COVIP studies. Baseline patient characteristics, interventions in intensive care unit (ICU) and outcomes (30-day survival) were recorded. COVID patients were matched to non-COVID patients based on the following factors: age (± 2 years), Sequential Organ Failure Assessment (SOFA) score (± 2 points), clinical frailty scale (± 1 point), gender and region on a 1:2 ratio. Specific ICU procedures and LLST were compared between the cohorts by means of cumulative incidence curves taking into account the competing risk of discharge and death.
results693 COVID patients were compared to 1393 non-COVID patients. COVID patients were younger, less frail, less severely ill with lower SOFA score, but were treated more often with invasive mechanical ventilation (MV) and had a lower 30-day survival. 404 COVID patients could be matched to 666 non-COVID patients. For COVID patients, withholding and withdrawing of LST were more frequent than for non-COVID and the 30-day survival was almost half compared to non-COVID patients.
conclusionVery old COVID patients have a different trajectory than non-COVID patients. Whether this finding is due to a decision policy with more active treatment limitation or to an inherent higher risk of death due to COVID-19 is unclear.
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