Evidence map›Paper›PMID 35218308›Full record

ReviewBrain and behavior2022

Unveiling the phantom: What neuroimaging has taught us about phantom limb pain.

Jonathan D Browne, Ryan Fraiser, Yi Cai, Dillon Leung, Albert Leung, Michael Vaninetti

Abstract readReview
In one paragraph

Review in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Long-term outcomes of spinal cord stimulation for refractory phantom limb pain.Frontiers in pain research (Lausanne, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonathan D BrowneSchool of Medicine, California University of Science and Medicine, Colton, California, USA.ORCID 0000-0002-6233-2997
Ryan FraiserCenter for Pain Medicine, University of California San Diego, La Jolla, California, USA.
Yi CaiCenter for Pain Medicine, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-2714-5384
Dillon LeungCollege of Letters and Science, University of California Berkeley, Berkeley, California, USA.
Albert LeungCenter for Pain Medicine, University of California San Diego, La Jolla, California, USA.
Michael VaninettiCenter for Pain Medicine, University of California San Diego, La Jolla, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phantom limb pain (PLP) is a complicated condition with diverse clinical challenges. It consists of pain perception of a previously amputated limb. The exact pain mechanism is disputed and includes mechanisms involving cerebral, peripheral, and spinal origins. Such controversy limits researchers' and clinicians' ability to develop consistent therapeutics or management. Neuroimaging is an essential tool that can address this problem. This review explores diffusion tensor imaging, functional magnetic resonance imaging, electroencephalography, and magnetoencephalography in the context of PLP. These imaging modalities have distinct mechanisms, implications, applications, and limitations. Diffusion tensor imaging can outline structural changes and has surgical applications. Functional magnetic resonance imaging captures functional changes with spatial resolution and has therapeutic applications. Electroencephalography and magnetoencephalography can identify functional changes with a strong temporal resolution. Each imaging technique provides a unique perspective and they can be used in concert to reveal the true nature of PLP. Furthermore, researchers can utilize the respective strengths of each neuroimaging technique to support the development of innovative therapies. PLP exemplifies how neuroimaging and clinical management are intricately connected. This review can assist clinicians and researchers seeking a foundation for applications and understanding the limitations of neuroimaging techniques in the context of PLP.

Indexed as

AmputeesPhantom LimbBrain MappingDiffusion Tensor ImagingHumansNeuroimagingDTIEEGfMRIMEGphantom limb pain

Identifiers

PMID35218308
PMCPMC8933774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.