ArticleActa obstetricia et gynecologica Scandinavica2022
The prognostic value of the number of positive lymph nodes and the lymph node ratio in early-stage cervical cancer.
Article in Acta obstetricia et gynecologica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prognostic values of lymph node ratio for gynecological cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Prognostic Survival Model Following Primary Radical Surgery for Early-Stage Cervical Cancer.Cancers · 2026Article
- Article
- Rationality of FIGO 2018 IIIC cervical cancer according to local tumor and pelvic lymph node metastatic extent-a cohort study.BMC women's health · 2025Article
- Risk stratification of node-positive early-stage cervical cancer treated with radical hysterectomy followed by chemoradiotherapy: a retrospective single-center study.Radiation oncology (London, England) · 2025Article
- Current Paradigm and Future Directions in the Management of Nodal Disease in Locally Advanced Cervical Cancer.Cancers · 2025Review
- Article
- Article
- Efficacy and safety of consolidation chemotherapy after adjuvant therapy in stage IB-IIA cervical cancer patients with risk factors: a retrospective single-center study.Frontiers in oncology · 2024Article
- The distribution pattern of pelvic lymph nodal metastases in cervical cancer.Journal of cancer research and clinical oncology · 2023Article
- Prognostic analysis of patients with stage IIIC1p cervical cancer treated by surgery.World journal of surgical oncology · 2023Article
- The prognostic value of the number of positive lymph nodes and the lymph node ratio in early-stage cervical cancer.Acta obstetricia et gynecologica Scandinavica · 2022Article
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6 authors.
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Abstract
introductionTo establish the impact of the number of lymph node metastases (nLNM) and the lymph node ratio (LNR) on survival in patients with early-stage cervical cancer after surgery. MATERIAL AND
methodsIn this nationwide historical cohort study, all women diagnosed between 1995 and 2020 with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA2-IIA1 cervical cancer and nodal metastases after radical hysterectomy and pelvic lymphadenectomy from the Netherlands Cancer Registry were selected. Optimal cut-offs for prognostic stratification by nLNM and LNR were calculated to categorize patients into low-risk or high-risk groups. Kaplan-Meier overall survival analysis and flexible parametric relative survival analysis were used to determine the impact of nLNM and LNR on survival. Missing data were imputed.
resultsThe optimal cut-off point was ≥4 for nLNM and ≥0.177 for LNR. Of the 593 women included, 500 and 501 (both 84%) were categorized into the low-risk and 93 and 92 (both 16%) into the high-risk groups for nLNM and LNR, respectively. Both high-risk groups had a worse 5-year overall survival (p < 0.001) compared with the low-risk groups. Being classified into the high-risk groups is an independent risk factor for relative survival, with excess hazard ratios of 2.4 (95% confidence interval 1.6-3.5) for nLNM and 2.5 (95% confidence interval 1.7-3.8) for LNR.
conclusionsPresenting a patient's nodal status postoperatively by the number of positive nodes, or by the nodal ratio, can support further risk stratification regarding survival in the case of node-positive early-stage cervical cancer.
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