Evidence map›Paper›PMID 35218194›Full record

Trial reportThe Journal of nutrition2022

Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial.

Kelsey A Schmidt, Roshonda B Jones, Claudia Rios, Yesica Corona, Paige K Berger, Jasmine F Plows, Tanya L Alderete, Jennifer Fogel, Hailey Hampson, Jaana A Hartiala and 10 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02948647 (Diets Based on PNPLA3 Genotype for Reducing Liver Fat in Hispanics With Pediatric Non-alcoholic Fatty Liver Disease), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02948647 nacompletednot on this map

Diets Based on PNPLA3 Genotype for Reducing Liver Fat in Hispanics With Pediatric Non-alcoholic Fatty Liver Disease

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2016 to 2021Enrolled113ConditionsNAFLDArmsStandard of care plus sugar-reduction education
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Article
  10. Associations of dietary sugars with liver stiffness in Latino adolescents with obesity differ on PNPLA3 and liver disease severity.Liver international : official journal of the International Association for the Study of the Liver · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Kelsey A SchmidtDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-9916-1634
Roshonda B JonesDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Claudia RiosDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Yesica CoronaDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Paige K BergerDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jasmine F PlowsDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Tanya L AldereteDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Jennifer FogelDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Hailey HampsonDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jaana A HartialaDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Zhiheng CaiDepartment of Biochemistry & Molecular Medicine, University of Southern California, Los Angeles, CA, USA.
Hooman AllayeeDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-2384-5239
Krishna S NayakDepartment of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, USA.
Frank R SinatraDepartment of Pediatrics, University of Southern California, Los Angeles, CA, USA.
Gregory HarlanDepartment of Pediatrics, University of Southern California, Los Angeles, CA, USA.
Trevor A PickeringDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-2281-641X
Sarah-Jeanne SalvyCancer Research Center for Health Equity, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Wendy Jean MackDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Rohit KohliDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Michael I GoranDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-6897-6961
Children's Hospital of Los Angeles · USUniversity of Southern California · USCedars-Sinai Medical Center · USUniversity of Colorado Boulder · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Project 2: Leveraging Ongoing Home Visitation Programs to Address Obesity Disparities among Underserved, Low-Income Mothers and ChildrenU54MD000502 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N. · 2017 to 2022
$11.8M
Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and ModeratorsR01CA258222 · NCI · CEDARS-SINAI MEDICAL CENTER · PI FIGUEIREDO, JANE C., PETERSON, COURTNEY MARIE · 2021 to 2025
$4.1M
Nutrigenetic Intervention to Reduce Liver Fat in Hispanics - SupplementR01MD010358 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN, GORAN, MICHAEL ISAAC · 2016 to 2019
$3.3M
In-home obesity prevention to reach low-income infants through maternal and social transmissionR01HD092483 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DE LA HAYE, KAYLA, SALVY, SARAH-JEANNE · 2017 to 2021
$2.7M
Role of Human Milk Oligosaccharides on Brain Development in Preterm InfantsR00HD098288 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BERGER, PAIGE KIMBERLY · 2022 to 2024
$686k
Role of Human Milk Oligosaccharides on Infant Brain DevelopmentK99HD098288 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BERGER, PAIGE KIMBERLY · 2020 to 2021
$180k
NCATS NIH HHS UL1 TR001855NCI NIH HHS R01 CA258222NICHD NIH HHS K99 HD098288NICHD NIH HHS R00 HD098288NICHD NIH HHS R01 HD092483NIMHD NIH HHS R01 MD010358NIMHD NIH HHS U54 MD000502
6 · The paper itself

Abstract

backgroundNonalcoholic fatty liver disease (NAFLD) among Latinos is partially attributed to a prevalent C>G polymorphism in the patatin-like phospholipase 3 (PNPLA3) gene. Cross-sectional analyses in Latino children showed the association between dietary sugar and liver fat was exacerbated by GG genotype. Pediatric feeding studies show extreme sugar restriction improves liver fat, but no prior trial has examined the impact of a clinical intervention or whether effects differ by PNPLA3 genotype.

objectivesWe aimed to test effects of a clinical intervention to reduce dietary sugar compared with standard dietary advice on change in liver fat, and secondary-endpoint changes in liver fibrosis, liver enzymes, and anthropometrics; and whether effects differ by PNPLA3 genotype (assessed retrospectively) in Latino youth with obesity (BMI ≥ 95th percentile).

methodsThis parallel-design trial randomly assigned participants (n = 105; mean baseline liver fat: 12.7%; mean age: 14.8 y) to control or sugar reduction (goal of ≤10% of calories from free sugar) for 12 wk. Intervention participants met with a dietitian monthly and received delivery of bottled water. Changes in liver fat, by MRI, were assessed by intervention group via general linear models.

resultsMean free sugar intake decreased in intervention compared with control [11.5% to 7.3% compared with 13.9% to 10.7% (% energy), respectively; P = 0.02], but there were no significant effects on liver outcomes or anthropometrics (Pall > 0.10), and no PNPLA3 interactions (Pall > 0.10). In exploratory analyses, participants with whole-body fat mass (FM) reduction (mean ± SD: -1.9 ± 2.4 kg), irrespective of randomization, had significant reductions in liver fat compared with participants without FM reduction (median: -2.1%; IQR: -6.5% to -0.8% compared with 0.3%; IQR: -1.0% to 1.1%; P < 0.001).

conclusionsIn Latino youth with obesity, a dietitian-led sugar reduction intervention did not improve liver outcomes compared with control, regardless of PNPLA3 genotype. Results suggest FM reduction is important for liver fat reduction, confirming clinical recommendations of weight loss and a healthy diet for pediatric NAFLD.This trial was registered at clinicaltrials.gov as NCT02948647.

Indexed as

Non-alcoholic Fatty Liver DiseaseAdolescentChildCross-Sectional StudiesDietary SugarsGenetic Predisposition to DiseaseGenotypeHispanic or LatinoHumansLipaseLiverMembrane ProteinsObesityPhospholipasesPolymorphism, Single NucleotideRetrospective StudiesDietary SugarsLipaseMembrane ProteinsPhospholipasesadolescentsLatinononalcoholic fatty liver diseasePNPLA3 genotypesugar

Identifiers

PMID35218194
PMCPMC9258557
OpenAlexW4213047368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.