ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
Racial differences in longitudinal Alzheimer's disease biomarkers among cognitively normal adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Lifetime risk of incident dementia and incident mild cognitive impairment in older adults.medRxiv : the preprint server for health sciences · 2025Article
- Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Intersectionality of gender with social determinants of health and asymptomatic Alzheimer's disease neuropathology.Journal of Alzheimer's disease : JAD · 2024Article
- Neuroimaging and biofluid biomarkers across race and ethnicity in older adults across the spectrum of cognition.Ageing research reviews · 2024Review
- Correlations between plasma markers and brain Aβ deposition across the AD continuum: Evidence from SILCODE.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals.Nature communications · 2024Article
- Atrophy links lower novelty-related locus coeruleus connectivity to cognitive decline in preclinical AD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Baseline levels and longitudinal rates of change in plasma Aβ42/40 among self-identified Black/African American and White individuals.Research square · 2024Article
- Influence of Gender on Tau Precipitation in Alzheimer's Disease According to ATN Research Framework.Phenomics (Cham, Switzerland) · 2023Article
- Biomarkers of Alzheimer's disease in Black and/or African American Alzheimer's Disease Neuroimaging Initiative (ADNI) participants.Neurobiology of aging · 2023Article
- The dynamics of plasma biomarkers across the Alzheimer's continuum.Alzheimer's research & therapy · 2023Article
- The iterative process of fluid biomarker development and validation in Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Racial and ethnic differences in plasma p-tau217 ratio biomarker eligibility rates in a preclinical AD trial with lecanemab.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
introductionLongitudinal changes in Alzheimer's disease (AD) biomarkers, including cerebrospinal fluid (CSF) analytes, amyloid uptakes from positron emission tomography (PET), structural outcomes from magnetic resonance imaging (MRI), and cognition, have not been compared between Blacks and Whites.
methodsA total of 179 Blacks and 1180 Whites who were cognitively normal at baseline and had longitudinal data from at least one biomarker modality were analyzed for the annual rates of change.
resultsCSF amyloid beta (Aβ)42/Aβ40 declined more slowly (P = .0390), and amyloid (PET) accumulated more slowly (P = .0157), in Blacks than Whites. CSF Aβ42 changed in opposite directions over time between Blacks and Whites (P = .0039). The annual increase in CSF total tau and phosphorylated tau181 for Blacks was about half of that for Whites. DISCUSSION: Longitudinal racial differences in amyloid biomarkers are observed. It will be important to comprehensively and prospectively examine the effects of apolipoprotein E genotype and sociocultural factors on these differences.
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