Evidence map›Paper›PMID 35218124›Full record

ArticlePediatric diabetes2022

Increase in newly diagnosed type 1 diabetes in youth during the COVID-19 pandemic in the United States: A multi-center analysis.

Risa M Wolf, Nudrat Noor, Roberto Izquierdo, Destiny Jett, Amanda Rewers, Shideh Majidi, Nicole Sheanon, Emily Breidbart, Carla Demeterco-Berggren, Joyce M Lee and 2 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Pediatric diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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  5. Trends of Diabetes in Youth (TrenDY) During COVID-19 Across the United States.The Journal of clinical endocrinology and metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

Risa M WolfDepartment of Pediatrics, Division of Pediatric Endocrinology, Johns Hopkins Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-7674-520X
Nudrat NoorT1D Exchange, Boston, Massachusetts, USA.
Roberto IzquierdoSUNY Upstate Medical University, Syracuse, New York, USA.
Destiny JettSUNY Upstate Medical University, Syracuse, New York, USA.
Amanda RewersBarbara Davis Center for Diabetes, Denver, Colorado, USA.
Shideh MajidiBarbara Davis Center for Diabetes, Denver, Colorado, USA.
Nicole SheanonCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Emily BreidbartNYU Langone Pediatrics, New York, New York, USA.
Carla Demeterco-BerggrenRady Children's Hospital, University of California, San Diego, California, USA.
Joyce M LeeMott Children's Hospital, Susan B. Meister Child Health Evaluation and Research Center, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8147-5168
Manmohan K KambojNationwide Children's Hospital, Columbus, Ohio, USA.
Osagie EbekozienT1D Exchange, Boston, Massachusetts, USA.ORCID 0000-0002-8473-249X
SUNY Upstate Medical University · USUniversity of Colorado Health · USCincinnati Children's Hospital Medical Center · USJackson Memorial Hospital · USJohns Hopkins University · USNationwide Children's Hospital · USNYU Langone Health · UST1D Exchange · USUniversity of California San Diego · USUniversity of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

backgroundAn increase in newly diagnosed type 1 diabetes (T1D) has been posited during the COVID-19 pandemic, but data are conflicting. We aimed to determine trends in newly diagnosed T1D and severity of presentation at diagnosis for pediatric and adolescent patients during COVID-19 (2020) as compared to the previous year (2019) in a multi-center analysis across the United States.

methodsThis retrospective study from seven centers in the T1D Exchange Quality Improvement Collaborative (T1DX-QI) included data on new onset T1D diagnosis and proportion in DKA at diagnosis from January 1 to December 31, 2020, compared to the prior year. Chi-square tests were used to compare differences in patient characteristics during the pandemic period compared to the prior year.

resultsAcross seven sites, there were 1399 newly diagnosed T1D patients in 2020, compared to 1277 in 2019 (p = 0.007). A greater proportion of newly diagnosed patients presented in DKA in 2020 compared to 2019 (599/1399(42.8%) vs. 493/1277(38.6%), p = 0.02), with a higher proportion presenting with severe DKA (p = 0.01) as characterized by a pH <7.1 and/or bicarbonate of <5 mmol/L. Monthly data trends demonstrated a higher number of new T1D diagnoses over the spring and summer months (March to September) of 2020 compared to 2019 (p < 0.001).

conclusionsWe found an increase in newly diagnosed T1D and a greater proportion presenting in DKA at diagnosis during the COVID-19 pandemic compared to the prior year. Future longitudinal studies are needed to confirm these findings with population level data and determine the long-term impact of COVID-19 on diabetes trends.

Indexed as

COVID-19Diabetes Mellitus, Type 1Diabetic KetoacidosisAdolescentChildHumansPandemicsRetrospective StudiesUnited StatesCOVID-19diabetic ketoacidosisnewly diagnosednew onsettype 1 diabetes

Identifiers

PMID35218124
PMCPMC9115477
OpenAlexW4214707898

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.