Evidence map›Paper›PMID 35217927›Full record

ArticleLangenbeck's archives of surgery2022

Postoperative acute pancreatitis after pancreatic resection in patients with pancreatic ductal adenocarcinoma.

Masaaki Murakawa, Yuto Kamioka, Shinnosuke Kawahara, Naoto Yamamoto, Satoshi Kobayashi, Makoto Ueno, Manabu Morimoto, Hiroshi Tamagawa, Takashi Ohshima, Norio Yukawa and 3 more

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In one paragraph

Article in Langenbeck's archives of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Masaaki MurakawaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ward, Yokohama, 241-8515, Japan. m.murakawa@kcch.jp.ORCID http://orcid.org/0000-0001-6140-7953
Yuto KamiokaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ward, Yokohama, 241-8515, Japan.
Shinnosuke KawaharaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ward, Yokohama, 241-8515, Japan.
Naoto YamamotoDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ward, Yokohama, 241-8515, Japan.
Satoshi KobayashiDepartment of Hepatobiliary Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ward, Yokohama, 241-8515, Japan.
Makoto UenoDepartment of Hepatobiliary Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ward, Yokohama, 241-8515, Japan.
Manabu MorimotoDepartment of Hepatobiliary Pancreatic Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ward, Yokohama, 241-8515, Japan.
Hiroshi TamagawaDepartment of Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Takashi OhshimaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ward, Yokohama, 241-8515, Japan.
Norio YukawaDepartment of Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Yasushi RinoDepartment of Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Munetaka MasudaDepartment of Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Soichiro MorinagaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ward, Yokohama, 241-8515, Japan.
Kanagawa Prefectural Hospital Organization · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPostoperative pancreatic fistula (POPF) is one of the major critical complications after pancreatic resection. Recently, postoperative acute pancreatitis (POAP), a new concept for a pancreatic-specific complication following pancreatic resection, has been advocated, and its association with POPF has been reported. The present study examined the clinical features of POAP and identified the associations of POAP with POPF and other postoperative morbidities in pancreatic ductal adenocarcinoma (PDAC) patients undergoing pancreatic resection.

methodsA total of 312 consecutive patients who underwent pancreatic resection for PDAC at our institution from 2013 to 2019 were enrolled in this study. POAP was defined as an elevated serum amylase level above the upper limit normal on postoperative day (POD) 0 or 1, based on Connor's definition. The severity of POPF was assessed by the International Study Group on Pancreatic Surgery definition.

resultsA total of 184 patients (58.9%) had POAP. POAP occurred in 58.5% of subtotal stomach-preserving pancreatoduodenectomy patients and 60% of distal pancreatectomy combined with splenectomy patients. The presence of POAP was significantly associated with the development of clinically relevant POPF, higher rates of severe morbidity, and a prolonged hospital stay after pancreatic resection. A multivariate analysis showed that the presence of POAP and elevated C-reactive protein levels on POD 3 were independent predictors of clinically relevant POPF after subtotal stomach-preserving pancreatoduodenectomy.

conclusionsPOAP is associated with the development of POPF, higher rates of severe morbidity, and a prolonged hospital stay after pancreatic resection and is an independent risk factor for clinically relevant POPF after pancreatoduodenectomy. POAP represents an important indicator for planning treatment strategies to prevent serious complications, including POPF.

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsPancreatitisAcute DiseaseHumansPancreatectomyPancreatic FistulaPancreaticoduodenectomyPostoperative ComplicationsRetrospective StudiesRisk FactorsPancreatic ductal adenocarcinomaPancreatic surgeryPostoperative acute pancreatitis (POAP)Postoperative complicationPostoperative pancreatic fistula (POPF)

Identifiers

PMID35217927
OpenAlexW4214584556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.