Evidence map›Paper›PMID 35217701›Full record

ArticleScientific reports2022

Development of a polymeric biomedical device platform with controlled disassembly and in vivo testing in a swine intestinal model.

Karrer M Alghazali, Alisha P Pedersen, Rabab N Hamzah, Pierre-Yves Mulon, Rebecca E Rifkin, Anwer Mhannawee, Zeid A Nima Alsudani, Christopher Griffin, Malek A H Muhi, Nikki Mullen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Karrer M Alghazali *Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, USA.
Alisha P Pedersen *Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
Rabab N HamzahCenter for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, USA.
Pierre-Yves MulonDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
Rebecca E RifkinDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
Anwer MhannaweeCenter for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, USA.
Zeid A Nima AlsudaniCenter for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, USA.
Christopher GriffinCenter for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, USA.
Malek A H MuhiCenter for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, USA.
Nikki MullenCenter for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, USA.
Robert L DonnellDepartment of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
David E AndersonDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA. dander48@utk.edu.
Alexandru S BirisCenter for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, USA. asbiris@ualr.edu.
University of Arkansas at Little Rock · USUniversity of Tennessee at Knoxville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to create a surgical guide platform that maintains its integrity while the surgeon performs an intestinal anastomosis or another similar procedure, which then breaks apart and is eliminated from the body in a controlled manner. The device contains mixed polymeric structures that give it a controlled rate of disassembly that could meet the requirements of a specific surgical purpose. The intraluminal anastomotic guide was manufactured as a hollow cylinder composed of layers of porous polyurethane/PCL with polyvinylpyrrolidone as the binding agent similar to a "brick-mortar" architecture. This combination of polymeric structures is a promising manufacturing method from which a variety of tunable devices can be fabricated for specific medical procedures and site-specific indications. The guide was designed to rapidly disassemble within the intestinal lumen after use, reliably degrading while maintaining sufficient mechanical rigidity and stability to support manipulation during complex surgical procedures. The nature of the device's disassembly makes it suitable for use in hollow structures that discharge their contents, resulting in their elimination from the body. A swine model of intestinal anastomosis was utilized to validate the use and function of the device.

Indexed as

Digestive System Surgical ProceduresIntestinesAnastomosis, SurgicalAnimalsPolymersPorositySwinePolymers

Identifiers

PMID35217701
PMCPMC8881572
OpenAlexW4214517727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.