Trial reportNature communications2022
Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases.
Trial report in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Egg excretion patterns of soil-transmitted helminth infections in humans following albendazole-ivermectin and albendazole treatment.PLoS neglected tropical diseases · 2024Trial
- Intestinal Parasites in School Children in Rural and Urban Areas in Kavrepalanchok, Nepal.EcoHealth · 2026Article
- Two key Actinomycetota taxa in the human gut microbiota are associated with Schistosoma mansoni infection burden.Parasitology research · 2026Article
- Comparison of Gut Microbiota and Metabolic Characteristics Between Miechongshu-Treated and Untreated Yili Horses.Animals : an open access journal from MDPI · 2026Article
- Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns.NPJ biofilms and microbiomes · 2026Article
- Widespread Trichuris incognita reveals hidden diversity and reshapes understanding of human whipworm infections.Nature communications · 2025Article
- Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers.NPJ biofilms and microbiomes · 2025Article
- Distinct gut microbiome features characterizeFrontiers in cellular and infection microbiology · 2025Article
- Gastrointestinal Parasites With Their Risk Factors in Tharu Indigenous People in Southern Nepal: A Cross-Sectional Study.Health science reports · 2025Article
- Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation.Communications biology · 2024Article
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- Regulation Effect ofMicroorganisms · 2024Article
- Baseline gut microbiota diversity and composition and albendazole efficacy in hookworm-infected individuals.Parasites & vectors · 2024Article
- Association between Food or Nutrients and Gut Microbiota in Healthy and Helminth-Infected Women of Reproductive Age from Zanzibar, Tanzania.Nutrients · 2024Article
- Taeniasis impacts human gut microbiome composition and function.The ISME journal · 2024Article
- Impact of Ivermectin on the Gut Microbial Ecosystem.International journal of molecular sciences · 2023Article
- The effect of single dose albendazole (400 mg) treatment on the human gut microbiome of hookworm-infected Ghanaian individuals.Scientific reports · 2023Article
- Polymeric Micelles Formulation of Combretastatin Derivatives with Enhanced Solubility, Cytostatic Activity and Selectivity against Cancer Cells.Pharmaceutics · 2023Article
- Networking between helminths, microbes, and mammals.Cell host & microbe · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soil-transmitted helminth infections represent a large burden with over a quarter of the world's population at risk. Low cure rates are observed with standard of care (albendazole); therefore, a more effective combination therapy (albendazole and ivermectin) is being investigated but showed variable treatment efficacies without evidence of intrinsic parasite resistance. Here, we analyzed the microbiome of Trichuris trichiura and hookworm-infected patients and found an association of different enterotypes with treatment efficacy. 80 T. trichiura-infected patients with hookworm co-infections from Pak-Khan, Laos, received either albendazole (n = 41) or albendazole and ivermectin combination therapy (n = 39). Pre-/post-treatment stool samples were collected to monitor treatment efficacy and microbial communities were profiled using 16S rRNA gene sequencing, qPCR, and shotgun sequencing. We identified three bacterial enterotypes and show that pre-treatment enterotype is associated with efficacy of the combination treatment for both T. trichiura (CR
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.