Evidence map›Paper›PMID 35217206›Full record

ArticleNeuroImage2022

An open access resource for functional brain connectivity from fully awake marmosets.

David J Schaeffer, L Martyn Klassen, Yuki Hori, Xiaoguang Tian, Diego Szczupak, Cecil Chern-Chyi Yen, Justine C Cléry, Kyle M Gilbert, Joseph S Gati, Ravi S Menon and 3 more

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Spacetime concordance in the primate cortex.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Unique Cortical and Subcortical Activation Patterns for Different Conspecific Calls in Marmosets.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  10. An open access resource for marmoset neuroscientific apparatus.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  11. Resting-state functional connectivity of the marmoset claustrum.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  12. Article
  13. Article
  14. Laminar Dynamics of Target Selection in the Posterior Parietal Cortex of the Common Marmoset.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

David J SchaefferDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, United States. Electronic address: dschaeff@pitt.edu.
L Martyn KlassenCentre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada.
Yuki HoriCentre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada.
Xiaoguang TianDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Diego SzczupakDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Cecil Chern-Chyi YenNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Justine C CléryCentre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada.
Kyle M GilbertCentre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada.
Joseph S GatiCentre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada.
Ravi S MenonCentre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
CiRong LiuInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
Stefan EverlingCentre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
Afonso C SilvaDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Western University · CAUniversity of Pittsburgh · USChinese Academy of Sciences · CNNational Institutes of Health · US

Funding

TREAT AD Structural Biology CoreU54AG065187 · NIA · EMORY UNIVERSITY · PI Gregory W Carter, ALLAN I LEVEY · 2019 to 2026
$69.7M
Veterinary and Colony Management CoreU19AG074866 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Afonso C Silva · 2022 to 2026
$44.9M
Spatial-Temporal Characterization of The Hemodynamic Response to Neural ActivityZIANS003041 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SILVA, AFONSO · 2009 to 2019
$17.1M
Development and Validation of a Marmoset Model of Late-Onset Alzheimer Disease Based on Tau SeedingR24AG073190 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SILVA, AFONSO C · 2021 to 2024
$4.5M
Spatial-Temporal Characterization of The Hemodynamic Response to Neural ActivityZ01NS003041 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI SILVA, AFONSO · 2007 to 2008
$2.5M
Intramural NIH HHS Z01 NS003041Intramural NIH HHS ZIA NS003041NIA NIH HHS R24 AG073190NIA NIH HHS U19 AG074866NIA NIH HHS U54 AG065187
6 · The paper itself

Abstract

The common marmoset (Callithrix jacchus) is quickly gaining traction as a premier neuroscientific model. However, considerable progress is still needed in understanding the functional and structural organization of the marmoset brain to rival that documented in longstanding preclinical model species, like mice, rats, and Old World primates. To accelerate such progress, we present the Marmoset Functional Brain Connectivity Resource (marmosetbrainconnectome.org), currently consisting of over 70 h of resting-state fMRI (RS-fMRI) data acquired at 500 µm isotropic resolution from 31 fully awake marmosets in a common stereotactic space. Three-dimensional functional connectivity (FC) maps for every cortical and subcortical gray matter voxel are stored online. Users can instantaneously view, manipulate, and download any whole-brain functional connectivity (FC) topology (at the subject- or group-level) along with the raw datasets and preprocessing code. Importantly, researchers can use this resource to test hypotheses about FC directly - with no additional analyses required - yielding whole-brain correlations for any gray matter voxel on demand. We demonstrate the resource's utility for presurgical planning and comparison with tracer-based neuronal connectivity as proof of concept. Complementing existing structural connectivity resources for the marmoset brain, the Marmoset Functional Brain Connectivity Resource affords users the distinct advantage of exploring the connectivity of any voxel in the marmoset brain, not limited to injection sites nor constrained by regional atlases. With the entire raw database (RS-fMRI and structural images) and preprocessing code openly available for download and use, we expect this resource to be broadly valuable to test novel hypotheses about the functional organization of the marmoset brain.

Indexed as

CallithrixWakefulnessAccess to InformationAnimalsBrainHumansMagnetic Resonance ImagingMiceRatsCommon marmosetFunctional connectivityNon-human primateOpen-access data resourceResting-state functional magnetic resonance imaging

Identifiers

PMID35217206
PMCPMC9048130
OpenAlexW4214526441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.