Evidence map›Paper›PMID 35217145›Full record

ReviewInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2022

Understanding on the possible routes for SARS CoV-2 invasion via ACE2 in the host linked with multiple organs damage.

Nikhil Kirtipal, Sanjay Kumar, Sumit Kumar Dubey, Vivek Dhar Dwivedi, K Gireesh Babu, Petr Malý, Shiv Bharadwaj

Open access · goldAbstract readReview
In one paragraph

Review in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Nikhil KirtipalSchool of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.
Sanjay KumarSchool of Biotechnology, Jawaharlal Nehru University, New Delhi, India; Centre for Bioinformatics, Computational and Systems Biology, Pathfinder Research and Training Foundation, Greater Noida, India.
Sumit Kumar DubeyNMDC International Inoculation Centre, New Delhi, India.
Vivek Dhar DwivediCentre for Bioinformatics, Computational and Systems Biology, Pathfinder Research and Training Foundation, Greater Noida, India. Electronic address: vivek_bioinformatics@yahoo.com.
K Gireesh BabuDepartment of Life Sciences, Parul Institute of Applied Sciences, Parul University, Limda, Vadodara, India. Electronic address: gireesh.k18684@paruluniversity.ac.in.
Petr MalýLaboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences v.v.i., BIOCEV Research Center, Vestec, Czech Republic. Electronic address: petr.maly@ibt.cas.cz.
Shiv BharadwajLaboratory of Ligand Engineering, Institute of Biotechnology of the Czech Academy of Sciences v.v.i., BIOCEV Research Center, Vestec, Czech Republic. Electronic address: shiv.bharadwaj@ibt.cas.cz.
Czech Academy of Sciences, Institute of Biotechnology · CZGwangju Institute of Science and Technology · KRJawaharlal Nehru University · INParul University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), accountable for causing the coronavirus diseases 2019 (COVID-19), is already declared as a pandemic disease globally. Like previously reported SARS-CoV strain, the novel SARS-CoV-2 also initiates the viral pathogenesis via docking viral spike-protein with the membranal angiotensin-converting enzyme 2 (ACE2) - a receptor on variety of cells in the human body. Therefore, COVID-19 is broadly characterized as a disease that targets multiple organs, particularly causing acute complications via organ-specific pathogenesis accompanied by destruction of ACE2

Indexed as

COVID-19SARS-CoV-2Angiotensin-Converting Enzyme 2HumansPandemicsPeptidyl-Dipeptidase AACE2 protein, humanAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase AAngiotensin-(1-7)COVID-19Extrapulmonary manifestationMultiorgan damagePneumoniaSARS-CoV-2

Identifiers

PMID35217145
PMCPMC8863418
OpenAlexW4214730659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.