Evidence map›Paper›PMID 35216865›Full record

ArticleSchizophrenia research2022

Perceptual pathways to hallucinogenesis.

Andrew D Sheldon, Eren Kafadar, Victoria Fisher, Maximillian S Greenwald, Fraser Aitken, Alyson M Negreira, Scott W Woods, Albert R Powers

Abstract read
In one paragraph

Article in Schizophrenia research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. The Future of Perceptual Dysregulation in Psychiatric Nosology.Current topics in behavioral neurosciences · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrew D SheldonYale University School of Medicine and the Connecticut Mental Health Center, New Haven, CT, United States of America.
Eren KafadarYale University School of Medicine and the Connecticut Mental Health Center, New Haven, CT, United States of America.
Victoria FisherYale University School of Medicine and the Connecticut Mental Health Center, New Haven, CT, United States of America.
Maximillian S GreenwaldYale University School of Medicine and the Connecticut Mental Health Center, New Haven, CT, United States of America.
Fraser AitkenSchool of Biomedical and Imaging Sciences, Kings College, London, UK.
Alyson M NegreiraCincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, USA.
Scott W WoodsYale University School of Medicine and the Connecticut Mental Health Center, New Haven, CT, United States of America.
Albert R PowersYale University School of Medicine and the Connecticut Mental Health Center, New Haven, CT, United States of America. Electronic address: albert.powers@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
A Hearing Test for Hallucinations: Toward Development of Computational Markers for Early DiagnosisK23MH115252 · NIMH · YALE UNIVERSITY · PI POWERS, ALBERT R · 2018 to 2022
$983k
Toward a Computationally-Informed, Personalized Treatment for HallucinationsR21MH122940 · NIMH · YALE UNIVERSITY · PI POWERS, ALBERT R · 2020 to 2021
$404k
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS T32 GM136651NIMH NIH HHS K23 MH115252NIMH NIH HHS R21 MH122940Wellcome Trust
6 · The paper itself

Abstract

Recent advances in computational psychiatry have provided unique insights into the neural and cognitive underpinnings of psychotic symptoms. In particular, a host of new data has demonstrated the utility of computational frameworks for understanding how hallucinations might arise from alterations in typical perceptual processing. Of particular promise are models based in Bayesian inference that link hallucinatory perceptual experiences to latent states that may drive them. In this piece, we move beyond these findings to ask: how and why do these latent states arise, and how might we take advantage of heterogeneity in that process to develop precision approaches to the treatment of hallucinations? We leverage specific models of Bayesian inference to discuss components that might lead to the development of hallucinations. Using the unifying power of our model, we attempt to place disparate findings in the study of psychotic symptoms within a common framework. Finally, we suggest directions for future elaboration of these models in the service of a more refined psychiatric nosology based on predictable, testable, and ultimately treatable information processing derangements.

Indexed as

HallucinationsPsychotic DisordersBayes TheoremCognitionHumansComputational psychiatryHallucinationsPerceptionPredictive coding

Identifiers

PMID35216865
PMCPMC9232894

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.