ArticleBiological psychiatry2022
Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Genetics and epigenetics of self-injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Pooled it
- Prevalence and Correlates of Suicide and Nonsuicidal Self-injury in Children: A Systematic Review and Meta-analysis.JAMA psychiatry · 2022Pooled it
- The Predictive Value of Preadolescent Suicidal Ideation Reporter Discrepancies in the ABCD Study.Child psychiatry and human development · 2026Article
- Investigating the associations between neurodevelopmental and psychiatric genetic liability and adverse social and functional outcomes across childhood, adolescence and young-adulthood.Molecular psychiatry · 2026Article
- Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review.Frontiers in pediatrics · 2026Review
- Do Self-Processes and Parenting Mediate the Effects of Anxious Parents' Psychopathology on Youth Depression and Suicidality?Child psychiatry and human development · 2025Article
- Validation of CBCL depression scores of adolescents in three independent datasets.JCPP advances · 2025Article
- Effect of Parental-Child Age Gaps and Skipped-Generation Families on Comorbidities Related to Attention Deficit Hyperactivity Disorder: A Population-Based Case-Control Study.Children (Basel, Switzerland) · 2025Article
- Uncovering Genetic Risk Beyond Diagnoses in Suicidal Thoughts and Behaviors: Insights frommedRxiv : the preprint server for health sciences · 2025Article
- Peripheral biological correlates of suicidality in children and adolescents: A systematic review and meta-analysis.iScience · 2025Article
- Optimization of self- or parent-reported psychiatric phenotypes in longitudinal studies.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Predicting adolescent psychopathology from early life factors: A machine learning tutorial.Global epidemiology · 2024Article
- Mediational pathways between aggregate genetic liability and nonfatal suicide attempt: A Swedish population-based cohort.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2024Article
- Disentangling heterogeneity in substance use disorder: Insights from genome-wide polygenic scores.Translational psychiatry · 2024Article
- Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits.Nature human behaviour · 2024Article
- Article
- Understanding the causal relationships of attention-deficit/hyperactivity disorder with mental disorders and suicide attempt: a network Mendelian randomisation study.BMJ mental health · 2023Article
- Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development.Nature neuroscience · 2023Article
- Association between suicidal ideation and tandem repeats inFrontiers in psychiatry · 2023Article
- Genetic Vulnerability for Preadolescent Suicidal Thoughts and Behaviors.Biological psychiatry · 2022Article
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11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSuicide is among the leading causes of death in children and adolescents. There are well-known risk factors of suicide, including childhood abuse, family conflicts, social adversity, and psychopathology. While suicide risk is also known to be heritable, few studies have investigated genetic risk in younger individuals.
methodsUsing polygenic risk score analysis, we examined whether genetic susceptibility to major psychiatric disorders is associated with suicidal behaviors among 11,878 children enrolled in the ABCD (Adolescent Brain Cognitive Development) Study. Suicidal ideation and suicide attempt data were assessed using the youth report of the Kiddie Schedule for Affective Disorders and Schizophrenia for DSM-5. After performing robust quality control of genotype data, unrelated individuals of European descent were included in analyses (n = 4344).
resultsAmong 8 psychiatric disorders we examined, depression polygenic risk scores were associated with lifetime suicide attempts both in the baseline (odds ratio = 1.55, 95% CI = 1.10-2.18, p = 1.27 × 10
conclusionsThe largest genetic sample of suicide risk data in U.S. children suggests a significant genetic basis of suicide risk related to attention-deficit/hyperactivity disorder and depression. Further research is warranted to examine whether incorporation of genomic risk may facilitate more targeted screening and intervention efforts.
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