ArticleCell2022
Multiple early factors anticipate post-acute COVID-19 sequelae.
2 registry-linked trialsAbstract read
In one paragraph
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 715 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
715citing papers in PubMed, 8 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT05808400 early_phase1unknown statusnot on this mapstarted 2023, after this paper: background citation
Clinical Study of the Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19 Infection
Epigenetic Changes in Long COVID Patients: Unraveling the Gut-Immune Axis and Therapeutic Targets
Who cites it
715 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Biomarkers of post-acute infection syndrome: a systematic literature review.Frontiers in immunology · 2026Pooled it
- Pooled it
- A bibliometric and text-mining analysis of lipidomics and metabolomics in human disease.Frontiers in physiology · 2026Pooled it
- Multi-omics time-series analysis in microbiome research: a systematic review.Briefings in bioinformatics · 2025Pooled it
- Long COVID and endometriosis: a systematic review and meta-analysis.BMC women's health · 2025Pooled it
- The Omics Landscape of Long COVID-A Comprehensive Systematic Review to Advance Biomarker, Target and Drug Discovery.Allergy · 2025Pooled it
- Antiphospholipid Antibodies and COVID-19: A Systematic Review of Clinical Implications.Immunity, inflammation and disease · 2025Pooled it
- Long COVID among people with HIV: A systematic review and meta-analysis.HIV medicine · 2025Pooled it
- Immunological effects of supervised exercise in long COVID in adults: A secondary analysis of a randomized crossover trial.Physiological reports · 2026Trial
- Cytomegalovirus DNAemia in Hospitalized Adults With SARS-CoV-2 Infection Requiring Supplemental Oxygen: Virologic and Clinical Characteristics and Association With Outcomes.The Journal of infectious diseases · 2026Trial
- Trial
- Association between psychological wellbeing and the COVID-19-related outcomes in Europeans aged ≥ 50 years old: The SHARE study.Human vaccines & immunotherapeutics · 2026Article
- Autoantibodies neutralizing type I interferons in COVID-19 patients from southern Brazil.Journal of human immunity · 2026Article
- High prevalence of autoantibodies neutralizing type I IFNs in Japanese patients with hepatitis C.Journal of human immunity · 2026Article
- Plasma Metabolomic Alterations Are Associated with T-Cell Senescence, Cytokine Dysregulation, and Prognosis in Elderly COVID-19 Patients.Biomedicines · 2026Article
- A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection.Immunity · 2026Article
- Glucagon-like peptide-1 receptor agonist prevents pulmonary fibrosis following acute COVID-19 infection associated with type 2 diabetes.Journal of virology · 2026Article
- Persistent cytolytic CD8Cell reports. Medicine · 2026Article
- Persistent Redox Imbalance in Post-COVID-19 Syndrome: Lipid Peroxidation, Antioxidant Enzyme Depletion, and Reduced Nitric Oxide Availability in an Amazonian Population.Antioxidants (Basel, Switzerland) · 2026Article
- β-Cell Dysfunction in COVID-19 and Post-COVID Syndrome: Molecular Mechanisms Linking Inflammation, Oxidative Stress, and Insulin Secretion.International journal of molecular sciences · 2026Review
655 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
74 authors.
Yapeng SuInstitute for Systems Biology, Seattle, WA 98109, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: suyapeng.tju@gmail.com.
Dan YuanInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.
Daniel G ChenInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Microbiology and Department of Informatics, University of Washington, Seattle, WA 98195, USA.
Rachel H NgInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.
Kai WangInstitute for Systems Biology, Seattle, WA 98109, USA.
Jongchan ChoiInstitute for Systems Biology, Seattle, WA 98109, USA.
Sarah LiInstitute for Systems Biology, Seattle, WA 98109, USA.
Sunga HongInstitute for Systems Biology, Seattle, WA 98109, USA.
Rongyu ZhangInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.
Jingyi XieInstitute for Systems Biology, Seattle, WA 98109, USA; Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98105, USA.
Sergey A KornilovInstitute for Systems Biology, Seattle, WA 98109, USA.
Kelsey ScherlerInstitute for Systems Biology, Seattle, WA 98109, USA.
Ana Jimena Pavlovitch-BedzykInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.
Shen DongDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Christopher LaustedInstitute for Systems Biology, Seattle, WA 98109, USA.
Inyoul LeeInstitute for Systems Biology, Seattle, WA 98109, USA.
Shannon FallenInstitute for Systems Biology, Seattle, WA 98109, USA.
Chengzhen L DaiInstitute for Systems Biology, Seattle, WA 98109, USA.
Priyanka BaloniInstitute for Systems Biology, Seattle, WA 98109, USA.
Brett SmithInstitute for Systems Biology, Seattle, WA 98109, USA.
Venkata R DuvvuriInstitute for Systems Biology, Seattle, WA 98109, USA.
Kristin G AndersonClinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Departments of Immunology and Medicine, University of Washington, Seattle, WA 98109, USA.
Jing LiInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.
Fan YangDepartment of Pathology, Stanford University, Stanford, CA 94304, USA.
Caroline J DuncombeDivision of Global Health, University of Washington, Seattle, WA 98105, USA.
Denise J McCullochDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA.
Clifford RostomilyInstitute for Systems Biology, Seattle, WA 98109, USA.
Pamela TroischInstitute for Systems Biology, Seattle, WA 98109, USA.
Jing ZhouIsoplexis Corporation, Branford, CT 06405, USA.
Sean MackayIsoplexis Corporation, Branford, CT 06405, USA.
Quinn DeGottardiAdaptive Biotechnologies, Seattle, WA 98109, USA.
Damon H MayAdaptive Biotechnologies, Seattle, WA 98109, USA.
Ruth TaniguchiAdaptive Biotechnologies, Seattle, WA 98109, USA.
Rachel M GittelmanAdaptive Biotechnologies, Seattle, WA 98109, USA.
Mark KlingerAdaptive Biotechnologies, Seattle, WA 98109, USA.
Thomas M SnyderAdaptive Biotechnologies, Seattle, WA 98109, USA.
Ryan RoperInstitute for Systems Biology, Seattle, WA 98109, USA.
Gladys WojciechowskaInstitute for Systems Biology, Seattle, WA 98109, USA; Medical University of Białystok, Białystok 15089, Poland.
Kim MurrayInstitute for Systems Biology, Seattle, WA 98109, USA.
Rick EdmarkInstitute for Systems Biology, Seattle, WA 98109, USA.
Simon EvansInstitute for Systems Biology, Seattle, WA 98109, USA.
Lesley JonesInstitute for Systems Biology, Seattle, WA 98109, USA.
Yong ZhouInstitute for Systems Biology, Seattle, WA 98109, USA.
Lee RowenInstitute for Systems Biology, Seattle, WA 98109, USA.
Rachel LiuInstitute for Systems Biology, Seattle, WA 98109, USA.
William ChourInstitute for Systems Biology, Seattle, WA 98109, USA.
Heather A AlgrenSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.
William R BerringtonSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.
Julie A WallickSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.
Rebecca A CochranSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.
Mary E MicikasSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.
ISB-Swedish COVID-19 Biobanking UnitInstitute for Systems Biology, Seattle, WA 98109, USA.
Terri WrinMonogram Biosciences, South San Francisco, CA 94080, USA.
Christos J PetropoulosMonogram Biosciences, South San Francisco, CA 94080, USA.
Hunter R ColeSt. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA.
Trevan D FischerSt. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA.
Wei WeiInstitute for Systems Biology, Seattle, WA 98109, USA.
Dave S B HoonSt. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA.
Nathan D PriceInstitute for Systems Biology, Seattle, WA 98109, USA.
Naeha SubramanianInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Global Heath and Department of Immunology, University of Washington, Seattle, WA 98109, USA.
Joshua A HillVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA.
Jennifer HadlockInstitute for Systems Biology, Seattle, WA 98109, USA.
Andrew T MagisInstitute for Systems Biology, Seattle, WA 98109, USA.
Antoni RibasDepartment of Medicine, University of California, Los Angeles, and Parker Institute for Cancer Immunotherapy, Los Angeles, CA 90095, USA.
Lewis L LanierDepartment of Microbiology and Immunology, University of California, San Francisco, and Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.
Scott D BoydDepartment of Pathology, Stanford University, Stanford, CA 94304, USA.
Jeffrey A BluestoneDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Helen ChuDivision of Global Health, University of Washington, Seattle, WA 98105, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA.
Leroy HoodInstitute for Systems Biology, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.
Raphael GottardoVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Statistics, University of Washington, Seattle, WA 98195, USA; Biomedical Data Sciences, Lausanne University Hospital, University of Lausanne, Lausanne, 1011, Switzerland.
Philip D GreenbergClinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Departments of Immunology and Medicine, University of Washington, Seattle, WA 98109, USA.
Mark M DavisInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jason D GoldmanVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA. Electronic address: jason.goldman@swedish.org.
James R HeathInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA. Electronic address: jim.heath@isbscience.org.
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MSystems Biology CoreU19AI128914 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Margaret Juliana McElrath, KENNETH D STUART · 2017 to 2026
$29.5MMOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0MThe effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2021 to 2025
$17.8MHOST DEFENSE TRAINING IN ALLERGY AND INFECTIOUS DISEASEST32AI007044 · NIAID · UNIVERSITY OF WASHINGTON · PI DAVID Neal FREDRICKS · 1985 to 2026
$14.6MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MNK MemoryR01AI068129 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2020
$6.0MHost innate immune mechanisms control temporal expression of flagellin by pathogenic SalmonellaR01AI155685 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI SUBRAMANIAN, NAEHA · 2021 to 2025
$2.6MAccelerated emphysema in HIV-infected smokers: the role of extracellular vesiclesR01DA040395 · NIDA · OHIO STATE UNIVERSITY · PI DIAZ, PHILIP T, NANASINKAM, SERGE PATRICK · 2015 to 2019
$2.5MNLRP3 inflammasome activation and its crosstalk with RLR signaling at the mitochondriaR01AI163131 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI SUBRAMANIAN, NAEHA · 2021 to 2025
$2.3MMicrofluidics Array Based Sorting, Isolation, and RNA Analysis in Single Extracellular V csiclesUG3TR002884 · NCATS · OHIO STATE UNIVERSITY · PI KIM, BETTY, REATEGUI, EDUARDO · 2019 to 2020
$822kCan a modest change in regulation of NOD1 expression have a major impact on inflammation and gastric cancer?R21AI138258 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI SUBRAMANIAN, NAEHA · 2018 to 2019
$523kNCATS NIH HHS UG3 TR002884NIAID NIH HHS P01 AI153559NIAID NIH HHS R01 AI068129NIAID NIH HHS R01 AI155685NIAID NIH HHS R01 AI163131NIAID NIH HHS R21 AI138258NIAID NIH HHS T32 AI007044NIAID NIH HHS T32 AI007290NIAID NIH HHS T32 AI007334NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI128914NIDA NIH HHS R01 DA040395
Abstract
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation of 309 COVID-19 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data and patient-reported symptoms. We resolved four PASC-anticipating risk factors at the time of initial COVID-19 diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, and specific auto-antibodies. In patients with gastrointestinal PASC, SARS-CoV-2-specific and CMV-specific CD8
Indexed as
ConvalescenceAdaptive ImmunityAdolescentAdultAgedAged, 80 and overAutoantibodiesBiomarkersBlood ProteinsCD8-Positive T-LymphocytesCOVID-19Disease ProgressionFemaleHumansImmunity, InnateLongitudinal StudiesAutoantibodiesBiomarkersBlood Proteinsantibodiesauto-antibodiescomputational biologyCOVID-19immune systemimmunologylong COVIDmetabolomicsmulti-omicsPASCproteomicsRNAemiasingle cellsingle-cell CITE-seqsingle-cell RNA-seqsingle-cell secretomesingle-cell TCR-seqsymptomstranscriptomeviremia
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT05808400ClinicalTrials.gov
NCT07757620ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.