ArticleImmunity2022
Tfh-cell-derived interleukin 21 sustains effector CD8
Abstract read
In one paragraph
Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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86citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
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Who cites it
86 citing papers in PubMed.
- Immune Hallmarks of Recurrent Immune Checkpoint Inhibitor-Mediated Inflammatory Arthritis.Cancer immunology research · 2026Article
- Tertiary lymphoid structures in cancer: their development, composition, clinical prognosis, and the drivers of the anti-tumor responses.Molecular biomedicine · 2026Review
- Clonal sharing and plasticity of follicular CD4 + T cells across lymph nodes and tumors in non-small cell lung cancer.Nature communications · 2026Article
- PD-1 regulates CD4Nature communications · 2026Article
- Vitamin B5 supports anti-PD1 response in HER2-positive gastric cancer and enhances interaction between naïve B cells and T cells.Nature communications · 2026Article
- Tumor-draining lymph nodes shape the tumor microenvironment through enrichment of tumor-reactive effector-exhausted CD8Signal transduction and targeted therapy · 2026Article
- Inflammatory arthritis irAE may represent a unique autoimmune disease primarily driven by T cells but likely not autoantibodies.Science advances · 2026Article
- Immune checkpoints in a genetically engineered mouse model of spontaneous autoimmune uveitis.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- T-Cell Immunity and Lung Cancer.Respirology (Carlton, Vic.) · 2026Review
- Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood.Science advances · 2026Article
- Stepwise differentiation from precursor intermediates and distinct Th1 checkpoints promote CD4 Th1 cell differentiation during chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Advances in IL-2 Family Cytokine-Based Cancer Therapies: Overcoming Challenges Through Molecular Engineering and Delivery Strategies.Immune network · 2026Review
- Regulators of CD8Nature reviews. Immunology · 2026Review
- Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causing autoimmune diseases through autoantibody production.Frontiers in immunology · 2026Article
- Thy1 retroviral reporters: a versatile platform for congenic background-independent adoptive transfer and CD8Frontiers in immunology · 2026Article
- Checkpoint-enriched T cells with retained effector-associated features are associated with disease activity in systemic lupus erythematosus.Frontiers in immunology · 2026Article
- SIGLEC15 modulates the immunosuppressive microenvironment and suppresses malignant phenotypes in triple-negative breast cancer.Genes & diseases · 2026Article
- Aberrant IL-21/STAT3 signaling disrupts regulatory T cell function and CD4Frontiers in immunology · 2026Article
- Mechanisms of T cell-mediated antitumor immunity within tertiary lymphoid structures.Frontiers in immunology · 2026Review
- Lactate bridges mesangial cells to the differentiation of follicular helper T cells in lupus nephritis.Nature communications · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Ryan ZanderBlood Research Institute, Versiti Wisconsin, Milwaukee, WI 53226, USA.
Moujtaba Y KasmaniBlood Research Institute, Versiti Wisconsin, Milwaukee, WI 53226, USA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Yao ChenBlood Research Institute, Versiti Wisconsin, Milwaukee, WI 53226, USA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Paytsar TopchyanBlood Research Institute, Versiti Wisconsin, Milwaukee, WI 53226, USA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Jian ShenBlood Research Institute, Versiti Wisconsin, Milwaukee, WI 53226, USA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Shikan ZhengBlood Research Institute, Versiti Wisconsin, Milwaukee, WI 53226, USA.
Robert BurnsBlood Research Institute, Versiti Wisconsin, Milwaukee, WI 53226, USA.
Jennifer IngramDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Can CuiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Nikhil JoshiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Joseph CraftDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Allan ZajacDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Weiguo CuiBlood Research Institute, Versiti Wisconsin, Milwaukee, WI 53226, USA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address: weiguo.cui@bcw.edu.
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0MIMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4MMedical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7MRegulation of T Cell Activity During Chronic InfectionsR01AI049360 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZAJAC, ALLAN J · 2001 to 2019
$4.1MPathogenesis of Lupus NephritisR01AI152443 · NIAID · YALE UNIVERSITY · PI Joseph Edgar Craft · 2020 to 2026
$3.8MPhenotypic, Functional and Transcriptional Heterogeneity in T Cell ExhaustionR01AI148403 · NIAID · VERSITI WISCONSIN, INC. · PI WEIGUO CUI · 2020 to 2026
$3.1MResistance to T cell exhaustionR01AI156290 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZAJAC, ALLAN J · 2021 to 2025
$2.7MThe Cellular and Transcriptional Control of CD8 T Cell Functional Adaptation to Chronic VirusesR01AI125741 · NIAID · VERSITI WISCONSIN, INC. · PI CUI, WEIGUO · 2016 to 2020
$2.1MFollicular Helper T Cell Function in AutoimmunityR01AR074545 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2019 to 2022
$1.3MDefining the transcriptional, phenotypic, and functional heterogeneity of virus-specific CD4 T cells during chronic viral infectionR00AI153537 · NIAID · UNIVERSITY OF IOWA · PI ZANDER, RYAN · 2022 to 2023
$498kDefining the transcriptional, phenotypic, and functional heterogeneity of virus-specific CD4 T cells during chronic viral infectionK99AI153537 · NIAID · VERSITI WISCONSIN, INC. · PI ZANDER, RYAN · 2020 to 2021
$224kNCATS NIH HHS UL1 TR001863NCI NIH HHS F30 CA246920NIAID NIH HHS K99 AI153537NIAID NIH HHS R00 AI153537NIAID NIH HHS R01 AI049360NIAID NIH HHS R01 AI125741NIAID NIH HHS R01 AI148403NIAID NIH HHS R01 AI152443NIAID NIH HHS R01 AI156290NIAMS NIH HHS R01 AR074545NIAMS NIH HHS R37 AR040072NIDDK NIH HHS F30 DK127526NIDDK NIH HHS P30 DK045735NIGMS NIH HHS T32 GM080202
Abstract
CD4
Indexed as
T Follicular Helper CellsVirus DiseasesCD8-Positive T-LymphocytesHumansInterleukin-21InterleukinsInterleukin-21InterleukinsATAC-seqCD4 T cellsIL-21LCMV Cl13single-cell RNA sequencing
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.