Evidence map›Paper›PMID 35216663›Full record

ReviewNeuron2022

Coordinating cerebral cortical construction and connectivity: Unifying influence of radial progenitors.

Cristine R Casingal, Katherine D Descant, E S Anton

Open access · greenAbstract readReview
In one paragraph

Review in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. FABP7 controls radial glial scaffold stability during human cortical development.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Topographic Axes of Wiring Space Converge to Genetic Topography in Shaping the Human Cortical Layout.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Article
  13. Article
  14. Brain development and bioenergetic changes.Neurobiology of disease · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Pediatric Brain Maturation and Migration Disorders.Diagnostics (Basel, Switzerland) · 2022
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cristine R CasingalUNC Neuroscience Center, the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Katherine D DescantUNC Neuroscience Center, the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
E S AntonUNC Neuroscience Center, the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: anton@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

DEFINING MECHANISMS OF PROGENITOR BALANCE AND NEURONAL CONNECTIVITYR35NS116859 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVA S ANTON · 2020 to 2026
$4.1M
Role of Radial Glial Tiling in the Formation and Malformation of the Cerebral CortexR01HD098657 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S · 2019 to 2023
$2.5M
NICHD NIH HHS R01 HD098657NINDS NIH HHS R35 NS116859
6 · The paper itself

Abstract

Radial progenitor development and function lay the foundation for the construction of the cerebral cortex. Radial glial scaffold, through its functions as a source of neurogenic progenitors and neuronal migration guide, is thought to provide a template for the formation of the cerebral cortex. Emerging evidence is challenging this limited view. Intriguingly, radial glial scaffold may also play a role in axonal growth, guidance, and neuronal connectivity. Radial glial cells not only facilitate the generation, placement, and allocation of neurons in the cortex but also regulate how they wire up. The organization and function of radial glial cells may thus be a unifying feature of the developing cortex that helps to precisely coordinate the right patterns of neurogenesis, neuronal placement, and connectivity necessary for the emergence of a functional cerebral cortex. This perspective critically explores this emerging view and its impact in the context of human brain development and disorders.

Indexed as

Cerebral CortexNeurogliaCell MovementEpendymoglial CellsHumansNeurogenesisNeuronsbrain evolutioncortical circuitscortical connectivitycorticogenesisneurodevelopmental disordersradial glia

Identifiers

PMID35216663
PMCPMC8989671
OpenAlexW4213451892

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.