Evidence map›Paper›PMID 35216638›Full record

ArticleBMC sports science, medicine & rehabilitation2022

Feasibility of a tailored home-based exercise intervention during neoadjuvant chemotherapy in breast cancer patients.

Kathleen M Sturgeon, Amanda M Smith, Elizabeth H Federici, Namratha Kodali, Renée Kessler, Edward Wyluda, Leah V Cream, Bonnie Ky, Kathryn H Schmitz

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC sports science, medicine & rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03280836 (Women In Steady Exercise Research - Neoadjuvant Exercise Trial), which is not on this map. Cited by 25 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03280836 nacompletednot on this map

Women In Steady Exercise Research - Neoadjuvant Exercise Trial

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2017 to 2020Enrolled19ConditionsBreast Neoplasm, Physical ActivityArmsExercise
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Exercise and pathologic complete response to cancer treatment: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  5. Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
    Pooled it
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  7. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kathleen M SturgeonDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. Kms99@psu.edu.ORCID http://orcid.org/0000-0001-9602-7897
Amanda M SmithSchool of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Elizabeth H FedericiDepartment of Hematology/Oncology, Penn State College of Medicine, Hershey, PA, USA.
Namratha KodaliDepartment of Hematology/Oncology, Penn State College of Medicine, Hershey, PA, USA.
Renée KesslerPenn State Health Medical Group, Andrews Patel Hematology/Oncology, Harrisburg, PA, USA.
Edward WyludaDepartment of Hematology/Oncology, Penn State College of Medicine, Hershey, PA, USA.
Leah V CreamDepartment of Hematology/Oncology, Penn State College of Medicine, Hershey, PA, USA.
Bonnie KySchool of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kathryn H SchmitzDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.

Funding

NRG Oncology NCORP Research Base-BIQSFPUG1CA189867 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Deborah Watkins Bruner, Lisa A. Kachnic · 2014 to 2026
$140.5M
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Penn State Institutional Career Development CoreKL2TR002015 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI VAN SCOY, LAUREN JODI · 2016 to 2025
$7.8M
division of cancer prevention, national cancer institute UG1CA189867NCATS NIH HHS KL2 TR002015NCATS NIH HHS KL2TR002015NCATS NIH HHS UL1 TR002014NCATS NIH HHS UL1TR002014NCI NIH HHS UG1 CA189867
6 · The paper itself

Abstract

purposeTo evaluate the feasibility of a home-based moderate-to-vigorous intensity, phased (introduction, intermediate, maintenance), exercise prescription in breast cancer patients receiving cardiotoxic neoadjuvant chemotherapy.

methodsNineteen breast cancer patients were randomized to intervention or control for the duration of chemotherapy (16-24 weeks). The intervention was one aerobic exercise session at 80-90% VO

results25.7% of eligible women consented (acceptability). Adherence was 87.6%. Women were not able to maintain exercise intensity as chemotherapy progressed (23.7% of exercise minutes were completed at prescribed heart rate during maintenance). Efficacy of the intervention was demonstrated by maintenance of VO

conclusionsNeoadjuvant breast cancer patients maintained approximately one hour/week of moderate-intensity exercise over the course of their treatment. Further, this volume of exercise was sufficient to maintain fitness capacity and quality of life compared to the control group. TRIAL REGISTRY: ClinicalTrials.gov Identifier: NCT03280836, prospectively registered 9/13/2017, https://clinicaltrials.gov/ct2/show/NCT03280836 .

Indexed as

Aerobic exerciseDrug therapyFitnessHome-basedQuality of life

Identifiers

PMID35216638
PMCPMC8874298

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.