ArticleCardiovascular diabetology2022
Triglyceride-glucose index trajectory and arterial stiffness: results from Hanzhong Adolescent Hypertension Cohort Study.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Investigating the association between the triglyceride-glucose index and peripheral artery disease: a systematic review and meta-analysis.Nutrition & diabetes · 2024Pooled it
- Triglyceride-glucose index and health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies.Cardiovascular diabetology · 2024Pooled it
- Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis.Cardiovascular diabetology · 2023Pooled it
- Association between triglyceride-glucose index and elevated blood pressure among U.S. adolescents aged 12-17.Pediatric research · 2026Article
- Article
- Impact of Cardiometabolic Risk Markers on the Incidence and Progression Arterial Stiffness in Patients With Prediabetes.Journal of diabetes · 2026Article
- The combined predictive value of the triglyceride-glucose index and A Body Shape Index on all-cause mortality: a 26-year prospective cohort analysis from the Rancho Bernardo Study.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Lipid profile dynamics and associated cardiovascular disease risk indices in Chinese people living with human immunodeficiency virus receiving antiretroviral therapy.BMC infectious diseases · 2026Article
- Association between the triglyceride-glucose index and subclinical atherosclerosis in asymptomatic adults: a large cross-sectional study of a health check-up population.Frontiers in cardiovascular medicine · 2026Article
- Comparison of the TyG index, TyG-traditional obesity indices, and TyG-novel obesity indices: does increased complexity help in predicting cardiometabolic multimorbidity?Lipids in health and disease · 2025Article
- Metabolic score for visceral fat (METS-VF) is associated with arterial stiffness progression in Type 2 diabetes: a retrospective cohort study of China.BMC endocrine disorders · 2025Article
- Triglyceride-glucose index for predicting the post-procedural wound healing of Rutherford grade 5 ischemia: a retrospective study.Scientific reports · 2025Article
- Association between the stress hyperglycemia ratio and elevated blood pressure among U.S. adolescents aged 12-17.Cardiovascular diabetology · 2025Article
- Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident stroke in middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS.Cardiovascular diabetology · 2025Article
- The association between triglyceride glucose-waist height ratio index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study.Cardiovascular diabetology · 2025Article
- Triglyceride-glucose index and risk of abdominal aortic aneurysm: a large-scale prospective cohort study.Diabetology & metabolic syndrome · 2025Article
- Association between Chinese visceral adiposity index and arterial stiffness among hospital workers in a Chinese tertiary hospital.Diabetology & metabolic syndrome · 2025Article
- Cumulative blood pressure load as a predictor of arterial stiffness progression and incident diabetic kidney disease: a multicenter longitudinal study.Cardiovascular diabetology · 2025Observational
- Long-term dual-trajectories of TyG and LAP and their association with cardiometabolic multimorbidity in midlife: the CARDIA study.Cardiovascular diabetology · 2025Article
- Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017-2020.BMC gastroenterology · 2025Article
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15 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe triglyceride-glucose index (TyG index) has emerged as a reliable surrogate marker of insulin resistance associated with arterial stiffness. However, most studies were based on a cross-sectional design, and few studies have evaluated the longitudinal impact of the TyG index on arterial stiffness. This study aimed to investigate the associations of single time point measurement and the long-term trajectory of the TyG index with arterial stiffness in a Chinese cohort.
methodsData are derived from the Hanzhong Adolescent Hypertension Cohort study. A total of 2480 individuals who participated in the 2017 survey was included in the cross-sectional analysis. A sample of 180 individuals from the sub-cohort with follow-up data in 2005, 2013, and 2017 was enrolled in the longitudinal analysis. The TyG index was calculated as ln (fasting triglyceride [mg/dL] × fasting glucose [mg/dL]/2), and arterial stiffness was determined using brachial-ankle pulse wave velocity (baPWV). The latent class growth mixture modeling method was used to identify the TyG index trajectories from 2005 to 2017.
resultsIn the cross-sectional analysis, the median age of the study population was 42.8 (39.8, 44.9) years, and 1351 (54.5%) were males. Each one-unit increment in TyG index was associated with a 37.1 cm/s increase (95% confidence interval [CI] 23.7-50.6 cm/s; P < 0.001) in baPWV, and similar results were observed when the TyG index was in the form of quartiles. In the longitudinal analysis, we identified three distinct TyG index trajectories and found that the highest TyG index trajectory carried the greatest odds of increased arterial stiffness, with a fully adjusted odds ratio (OR) of 2.76 (95% CI 1.40, 7.54).
conclusionsElevated levels of baseline TyG index and higher long-term trajectory of TyG index were independently associated with increased arterial stiffness. Monitoring immediate levels and longitudinal trends of the TyG index may help with the prevention of arterial stiffness in the long run.
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