Evidence map›Paper›PMID 35216573›Full record

SynthesisBMC pregnancy and childbirth2022

Psychiatric vulnerability and the risk for unintended pregnancies, a systematic review and meta-analysis.

N N Schonewille, N Rijkers, A Berenschot, J G Lijmer, O A van den Heuvel, B F P Broekman

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  17. Interest in Contraceptive Information and Initiation Among Adolescents Hospitalized With Psychiatric Disorders.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025
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  19. Contraceptive use and counselling in women with mental illness: KwaZulu-Natal, South Africa.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

N N SchonewilleDepartment Psychiatry and Medical Psychology, OLVG, Oosterpark 9, 1091 AC, Amsterdam, Netherlands. n.n.schonewille@olvg.nl.
N RijkersDepartment Psychiatry and Medical Psychology, OLVG, Oosterpark 9, 1091 AC, Amsterdam, Netherlands.
A BerenschotMedical Library, OLVG, Oosterpark 9, 1091 AC, Amsterdam, Netherlands.
J G LijmerDepartment Psychiatry and Medical Psychology, OLVG, Oosterpark 9, 1091 AC, Amsterdam, Netherlands.
O A van den HeuvelDepartment Psychiatry and Department Anatomy & Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Boelelaan 1118, 1081 HV, Amsterdam, Netherlands.
B F P BroekmanDepartment Psychiatry and Medical Psychology, OLVG, Oosterpark 9, 1091 AC, Amsterdam, Netherlands.
Vrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnintended pregnancies (UPs) are a global health problem as they contribute to adverse maternal and offspring outcomes, which underscores the need for prevention. As psychiatric vulnerability has previously been linked to sexual risk behavior, planning capacities and compliance with contraception methods, we aim to explore whether it is a risk factor for UPs.

methodsElectronic databases were searched in November 2020. All articles in English language with data on women with age ≥ 18 with a psychiatric diagnosis at time of conception and reported pregnancy intention were included, irrespective of obstetric outcome (fetal loss, livebirth, or abortion). Studies on women with intellectual disabilities were excluded. We used the National Institutes of Health tool for assessment of bias in individual studies and the Grading of Recommendations Assessment, Development and Evaluation method for assessment of quality of the primary outcome.

findingsEleven studies reporting on psychiatric vulnerability and UPs were included. The participants of these studies were diagnosed with mood, anxiety, psychotic, substance use, conduct and eating disorders. The studies that have been conducted show that women with a psychiatric vulnerability (n = 2650) have an overall higher risk of UPs compared to women without a psychiatric vulnerability (n = 16,031) (OR 1.34, CI 1.08-1.67) and an overall weighed prevalence of UPs of 65% (CI 0.43-0.82) (n = 3881).

interpretationStudies conducted on psychiatric vulnerability and UPs are sparse and many (common) psychiatric vulnerabilities have not yet been studied in relation to UPs. The quality of the included studies was rated fair to poor due to difficulties with measuring the outcome pregnancy intention (use of various methods of assessment and use of retrospective study designs with risk of bias) and absence of a control group in most of the studies. The findings suggest an increased risk of UPs in women with psychiatric vulnerability. As UPs have important consequences for mother and child, discussing family planning in women with psychiatric vulnerabilities is of utmost importance.

Indexed as

AdultFemaleHumansMental DisordersPregnancyPregnancy, UnplannedPrevalenceRisk FactorsSocial Determinants of HealthVulnerable PopulationsFamily planningMental healthPerinatal psychiatryPregnancy intentionPsychiatryReproductive healthSexual risk behaviorUnintended pregnancy

Identifiers

PMID35216573
PMCPMC8876535
OpenAlexW4214587318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.