Evidence map›Paper›PMID 35216530›Full record

ReviewAnnual review of analytical chemistry (Palo Alto, Calif.)2022

Technologies for Frugal and Sensitive Point-of-Care Immunoassays.

David S Kinnamon, Jacob T Heggestad, Jason Liu, Ashutosh Chilkoti

Abstract readReview
In one paragraph

Review in Annual review of analytical chemistry (Palo Alto, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. A Rapid and Modular Nanobody Assay for Plug-and-Play Antigen Detection.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David S KinnamonDepartment of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, USA; email: chilkoti@duke.edu.
Jacob T HeggestadDepartment of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, USA; email: chilkoti@duke.edu.
Jason LiuDepartment of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, USA; email: chilkoti@duke.edu.
Ashutosh ChilkotiDepartment of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, USA; email: chilkoti@duke.edu.

Funding

A Fully Integrated Point-of-Care Test for EbolaR01AI150888 · NIAID · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2020 to 2024
$3.4M
Point-of-care cellular and molecular pathology of breast tumors on a cell phoneR01CA248491 · NCI · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH, HWANG, E. SHELLEY · 2020 to 2024
$2.9M
Smartphone Enabled Point-of-Care Detection of Serum Markers of Liver CancerUH3CA211232 · NCI · DUKE UNIVERSITY · PI CHAO, NELSON J., CHILKOTI, ASHUTOSH · 2019 to 2021
$1.9M
Multiplex point-of-care test for diagnosis, prognosis and serology of COVID19R01AI159992 · NIAID · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2021 to 2023
$1.5M
NCI NIH HHS R01 CA248491NCI NIH HHS UH3 CA211232NIAID NIH HHS R01 AI150888NIAID NIH HHS R01 AI159992
6 · The paper itself

Abstract

Immunoassays are a powerful tool for sensitive and quantitative analysis of a wide range of biomolecular analytes in the clinic and in research laboratories. However, enzyme-linked immunosorbent assay (ELISA)-the gold-standard assay-requires significant user intervention, time, and clinical resources, making its deployment at the point-of-care (POC) impractical. Researchers have made great strides toward democratizing access to clinical quality immunoassays at the POC and at an affordable price. In this review, we first summarize the commercially available options that offer high performance, albeit at high cost. Next, we describe strategies for the development of frugal POC assays that repurpose consumer electronics and smartphones for the quantitative detection of analytes. Finally, we discuss innovative assay formats that enable highly sensitive analysis in the field with simple instrumentation.

Indexed as

Point-of-Care SystemsSmartphoneBiological AssayEnzyme-Linked Immunosorbent AssayImmunoassayPoint-of-Care Testingaffordablediagnosticsfrugal detectorsimmunoassayssmartphone

Identifiers

PMID35216530
PMCPMC10024863

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.