Evidence map›Paper›PMID 35216466›Full record

ReviewInternational journal of molecular sciences2022

Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics.

Tamara Timic Stamenic, Slobodan M Todorovic

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. All Organisms Can Be Anesthetized, but There's No Point?BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  2. Review
  3. Role of Thalamic CaInternational journal of molecular sciences · 2025
    Article
  4. Role of Mitochondrial Dysfunction in Neuropathy.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. CaInternational journal of molecular sciences · 2022
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tamara Timic StamenicDepartment of Anesthesiology, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.
Slobodan M TodorovicDepartment of Anesthesiology, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.
University of Colorado Anschutz Medical Campus · US

Funding

Voltage-gated calcium channels as target for anestheticsR35GM141802 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Slobodan M. Todorovic · 2021 to 2026
$3.1M
Novel neurosteroid anesthetics and perioperative analgesiaR01GM123746 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JEVTOVIC-TODOROVIC, VESNA · 2017 to 2025
$2.2M
NIGMS NIH HHS R01 GM123746NIGMS NIH HHS R35 GM141802NIH HHS GM141802-01
6 · The paper itself

Abstract

General anesthetics mainly act by modulating synaptic inhibition on the one hand (the potentiation of GABA transmission) or synaptic excitation on the other (the inhibition of NMDA receptors), but they can also have effects on numerous other proteins, receptors, and channels. The effects of general anesthetics on ion channels have been the subject of research since the publication of reports of direct actions of these drugs on ion channel proteins. In particular, there is considerable interest in T-type voltage-gated calcium channels that are abundantly expressed in the thalamus, where they control patterns of cellular excitability and thalamocortical oscillations during awake and sleep states. Here, we summarized and discussed our recent studies focused on the Ca

Indexed as

Anesthetics, GeneralAnimalsCalcium Channels, T-TypeHumansHypnotics and SedativesMembrane PotentialsMiceNeuronsAnesthetics, GeneralCalcium Channels, T-TypeHypnotics and SedativesEEG recordinggeneral anesthesiahypnosisLFP recordingnonspecific thalamust-type calcium channels

Identifiers

PMID35216466
PMCPMC8876360
OpenAlexW4213173783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.