Evidence map›Paper›PMID 35216458›Full record

ArticleInternational journal of molecular sciences2022

Hypoxia-Inducible Factor-2 Alpha Regulates the Migration of Fibroblast-like Synoviocytes via Oxidative Stress-Induced CD70 Expression in Patients with Rheumatoid Arthritis.

Su-Jin Yoo, Ha-Reum Lee, Jinhyun Kim, In Seol Yoo, Chan Keol Park, Seong Wook Kang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Su-Jin YooDivision of Rheumatology, Department of Internal Medicine, Chungnam National University Hospital, 282 Munhwaro, Daejeon 35015, Korea.ORCID 0000-0003-4620-8803
Ha-Reum LeeDivision of Rheumatology, Department of Internal Medicine, Chungnam National University Hospital, 282 Munhwaro, Daejeon 35015, Korea.
Jinhyun KimDivision of Rheumatology, Department of Internal Medicine, Chungnam National University Hospital, 282 Munhwaro, Daejeon 35015, Korea.
In Seol YooDivision of Rheumatology, Department of Internal Medicine, Chungnam National University Sejong Hospital, 20 Bodeum-7-ro, Sejong 30099, Korea.ORCID 0000-0002-5380-5895
Chan Keol ParkDivision of Rheumatology, Department of Internal Medicine, Chungnam National University Sejong Hospital, 20 Bodeum-7-ro, Sejong 30099, Korea.
Seong Wook KangDivision of Rheumatology, Department of Internal Medicine, Chungnam National University Hospital, 282 Munhwaro, Daejeon 35015, Korea.ORCID 0000-0002-0076-0822
Chungnam National University · KRChungnam National University Hospital · KR

Funding

Chungnam National University Hospital Research Fund 2018National Research Foundation of Korea NRF-2021R1G1A1005712the research fund of Rheumatology Research Foundation RRF-2017-05
6 · The paper itself

Abstract

This study aimed to examine the role of CD70, which is highly expressed on fibroblast-like synoviocytes (FLS), in rheumatoid arthritis (RA) patients. FLS isolated from RA (

Indexed as

Arthritis, RheumatoidBasic Helix-Loop-Helix ProteinsCD27 LigandOsteoarthritisOxidative StressSynoviocytesCells, CulturedEndothelial PAS Domain-Containing Protein 1FibroblastsHumansHypoxiaInterleukin-17Reactive Oxygen SpeciesSynovial MembraneTumor Necrosis Factor-alphaBasic Helix-Loop-Helix ProteinsCD27 LigandCD70 protein, humanEndothelial PAS Domain-Containing Protein 1Interleukin-17Reactive Oxygen SpeciesTumor Necrosis Factor-alphaantioxidantscytokinesreactive oxygen speciesrheumatoid arthritissynovial fluid

Identifiers

PMID35216458
PMCPMC8877612
OpenAlexW4214673481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.