Evidence map›Paper›PMID 35216446›Full record

ArticleInternational journal of molecular sciences2022

Engineered Zinc Finger Protein Targeting 2LTR Inhibits HIV Integration in Hematopoietic Stem and Progenitor Cell-Derived Macrophages: In Vitro Study.

Koollawat Chupradit, Wannisa Khamaikawin, Supachai Sakkhachornphop, Chaniporn Puaninta, Bruce E Torbett, Suparerk Borwornpinyo, Suradej Hongeng, Methichit Wattanapanitch, Chatchai Tayapiwatana

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Koollawat ChupraditSiriraj Center for Regenerative Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Wannisa KhamaikawinFaculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.ORCID 0000-0001-6766-6841
Supachai SakkhachornphopResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Chaniporn PuanintaDepartment of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Bruce E TorbettDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Suparerk BorwornpinyoDepartment of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Suradej HongengExcellent Center for Drug Discovery, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-7376-9393
Methichit WattanapanitchSiriraj Center for Regenerative Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.ORCID 0000-0003-2508-5760
Chatchai TayapiwatanaCenter of Biomolecular Therapy and Diagnostic, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Chiang Mai University · THMahidol University · THSiriraj Hospital · THKing Mongkut's Institute of Technology Ladkrabang · THScripps Research Institute · US

Funding

AMS Research Grant of Faculty of Associated Medical Sciences, Chiang Mai UniversityCMU Junior Research Fellowship ProgramFundamental Fund 2022, Chiang Mai UniversityKing Mongkut's Institute of Technology Ladkrabang 2563-0216006the Distinguished Research Professor Grant of the National Research Council of Thailand NRCT 808/2563the Office of National Higher Education Science Research and Innovation Policy Council (NXPO), Thailand, through Program Management Unit for Competitiveness (PMU C) C10F630145the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation RGNS 63-067the Program Management Unit for Human Resources and Institutional Development, Research and Innovation B05F630102
6 · The paper itself

Abstract

Human hematopoietic stem/progenitor cell (HSPC)-based gene therapy is a promising direction for curing HIV-1-infected individuals. The zinc finger protein (2LTRZFP) designed to target the 2-LTR-circle junction of HIV-1 cDNA was previously reported as an intracellular antiviral molecular scaffold that prevents HIV integration. Here, we elucidate the efficacy and safety of using 2LTRZFP in human CD34

Indexed as

Antigens, CD34Genetic TherapyHematopoietic Stem CellsHIV-1HIV InfectionsHumansMacrophagesStem CellsZinc FingersAntigens, CD34anti-HIV-1 scaffoldgene therapyhematopoietic stem/progenitor cellzinc finger domainzinc finger protein

Identifiers

PMID35216446
PMCPMC8875109
OpenAlexW4214580978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.