Evidence map›Paper›PMID 35216431›Full record

ArticleInternational journal of molecular sciences2022

Using Graphene-Based Materials for Stiff and Strong Poly(ethylene glycol) Hydrogels.

Helena P Ferreira, Duarte Moura, Andreia T Pereira, Patrícia C Henriques, Cristina C Barrias, Fernão D Magalhães, Inês C Gonçalves

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. PCL/Graphene Scaffolds for the Osteogenesis Process.Bioengineering (Basel, Switzerland) · 2023
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Helena P Ferreirai3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Duarte Mourai3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Andreia T Pereirai3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Patrícia C Henriquesi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.ORCID 0000-0002-4879-7886
Cristina C Barriasi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Fernão D MagalhãesLEPABE-Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.ORCID 0000-0002-4447-4473
Inês C Gonçalvesi3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.ORCID 0000-0001-9759-4965

Funding

Fundação para a Ciência e Tecnologia 2020.04712.BDFundação para a Ciência e Tecnologia CECINST/00091/2018/CP1500/CT0013Fundação para a Ciência e Tecnologia POCI-01-0145-FEDER-032431Fundação para a Ciência e Tecnologia SFRH/BD/1400006/2018Fundação para a Ciência e Tecnologia UIDB/00511/2020Fundação para a Ciência e Tecnologia UIDB/04293/2020
6 · The paper itself

Abstract

Blood-contacting devices are increasingly important for the management of cardiovascular diseases. Poly(ethylene glycol) (PEG) hydrogels represent one of the most explored hydrogels to date. However, they are mechanically weak, which prevents their use in load-bearing biomedical applications (e.g., vascular grafts, cardiac valves). Graphene and its derivatives, which have outstanding mechanical properties, a very high specific surface area, and good compatibility with many polymer matrices, are promising candidates to solve this challenge. In this work, we propose the use of graphene-based materials as nanofillers for mechanical reinforcement of PEG hydrogels, and we obtain composites that are stiffer and stronger than, and as anti-adhesive as, neat PEG hydrogels. Results show that single-layer and few-layer graphene oxide can strengthen PEG hydrogels, increasing their stiffness up to 6-fold and their strength 14-fold upon incorporation of 4%

Indexed as

AdhesivesBiocompatible MaterialsCell LineGraphiteHumansHuman Umbilical Vein Endothelial CellsHydrogelsPolyethylene GlycolsPolymersTissue EngineeringAdhesivesBiocompatible Materialsgraphene oxideGraphiteHydrogelsPolyethylene GlycolsPolymersanti-adhesive surfacebiomaterialscardiovascular applicationsgraphene oxidePEGtensile strength

Identifiers

PMID35216431
PMCPMC8880715

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.