Evidence map›Paper›PMID 35216422›Full record

ArticleInternational journal of molecular sciences2022

Vitamin D and Calcium Supplementation Accelerate Vascular Calcification in a Model of Pseudoxanthoma Elasticum.

Elise Bouderlique, Ellie Tang, Jeremy Zaworski, Amélie Coudert, Dominique Bazin, Ferenc Borondics, Jean-Philippe Haymann, Georges Leftheriotis, Ludovic Martin, Michel Daudon and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
  5. Article
  6. Considerations on the Development of Therapeutics in Vascular Calcification.Journal of cardiovascular development and disease · 2025
    Review
  7. Article
  8. [Advances in Animal Modeling in the Study of Bone-Vascular Axis Comorbidities].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Elise BouderliqueUMR S 1155, Sorbonne Université, 75020 Paris, France.
Ellie TangUMR S 1155, Sorbonne Université, 75020 Paris, France.
Jeremy ZaworskiUMR S 1155, Sorbonne Université, 75020 Paris, France.ORCID 0000-0003-1175-0440
Amélie CoudertUFR d'odontologie (Département des Sciences Biologiques), Université Paris Diderot BIOSCAR-INSERM U1132, Hôpital Lariboisière, 75010 Paris, France.
Dominique BazinLaboratoire de Physique des Solides, CNRS UMR 8502, Université Paris Sud XI, 91405 Orsay, France.ORCID 0000-0002-5112-9061
Ferenc BorondicsSynchrotron Soleil, L'Orme des Merisiers, Saint-Aubin-BP48, CEDEX, 91192 Gif-sur-Yvette, France.ORCID 0000-0001-9975-4301
Jean-Philippe HaymannUMR S 1155, Sorbonne Université, 75020 Paris, France.ORCID 0000-0002-2756-2287
Georges LeftheriotisLaboratory of Physiology and Molecular Medicine (LP2M), CNRS-UNS UMR 7370, University of Nice, 28 rue de Valombrose, CEDEX 2, 06107 Nice, France.
Ludovic MartinMITOVASC Institute-UMR CNRS 6015 INSERM U1083 Angers University, 49100 Angers, France.
Michel DaudonUMR S 1155, Sorbonne Université, 75020 Paris, France.
Emmanuel LetavernierUMR S 1155, Sorbonne Université, 75020 Paris, France.
Inserm · FRCentre National de la Recherche Scientifique · FRSynchrotron soleil · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arterial calcification is a common feature of pseudoxanthoma elasticum (PXE), a disease characterized by

methodswe analyzed whether long-term exposure of Abcc6

resultsat 6 months, although vitamin D and/or calcium did not significantly increase serum calcium levels, vitamin D and calcium supplementation significantly worsened aorta and renal artery calcification in Abcc6

conclusionsvitamin D and/or calcium supplementation accelerate vascular calcification in a murine model of PXE. These results sound a warning regarding the use of these supplementations in PXE patients and, to a larger extent, patients with low systemic pyrophosphate levels.

Indexed as

AnimalsArteriesATP-Binding Cassette, Sub-Family C ProteinsCalcification, PhysiologicCalciumCalcium, DietaryDietary SupplementsDisease Models, AnimalFemaleMicePseudoxanthoma ElasticumVascular CalcificationVitamin DATP-Binding Cassette, Sub-Family C ProteinsCalciumCalcium, DietaryVitamin DABCC6calcificationcalciumpseudoxanthoma elasticumpyrophosphatevascularvitamin D

Identifiers

PMID35216422
PMCPMC8878394
OpenAlexW4212920460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.