Evidence map›Paper›PMID 35216402›Full record

ArticleInternational journal of molecular sciences2022

Involvement of Histamine H

Kazuhiro Kiyohara, Daisuke Uta, Yuuya Nagaoka, Yurika Kino, Hideki Nonaka, Midori Ninomiya-Baba, Takuya Fujita

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Virtual Screening, Synthesis and In Vitro Characterization of Histamine HInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kazuhiro KiyoharaResearch Unit/Neuroscience, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan.ORCID 0000-0002-7284-7046
Daisuke UtaDepartment of Applied Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-5644-1348
Yuuya NagaokaResearch Unit/Neuroscience, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan.
Yurika KinoDigital Transformation Department, Mitsubishi Tanabe Pharma Corporation, Tokyo 100-8205, Japan.
Hideki NonakaResearch Unit/Neuroscience, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan.
Midori Ninomiya-BabaResearch Unit/Neuroscience, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan.
Takuya FujitaResearch Unit/Neuroscience, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama 227-0033, Japan.

Funding

Adaptable and Seamless Technology Transfer Program through Target-driven R&D from the Japan Science and Technology Agency JPMJTM20DNGrants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science KAKENHI JP19K09323, JP15K08667, JP25860431, and JP21600005Mitsubishi Tanabe Pharma Corporation No number
6 · The paper itself

Abstract

Several of the drugs currently available for the treatment of premature ejaculation (PE) (e.g., local anesthetics or antidepressants) are associated with numerous safety concerns and exhibit weak efficacy. To date, no therapeutics for PE have been approved in the United States, highlighting the need to develop novel agents with sufficient efficacy and fewer side effects. In this study, we focused on the histamine H

Indexed as

AnimalsHistamineHistamine AgonistsImidazolesMalePiperidinesPremature EjaculationRatsRats, WistarReceptors, Histamine H3ThioureaciproxifanHistamineHistamine AgonistsimetitImidazolesPiperidinesReceptors, Histamine H3Thioureacopulatory behaviorelectrophysiologyH3Rhistamine H3 receptorin vivo extracellular recordingpremature ejaculation

Identifiers

PMID35216402
PMCPMC8878335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.