Evidence map›Paper›PMID 35216371›Full record

ArticleInternational journal of molecular sciences2022

Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy.

Jacopo Morroni, Leonardo Schirone, Valentina Valenti, Clemens Zwergel, Carles Sánchez Riera, Sergio Valente, Daniele Vecchio, Sonia Schiavon, Rino Ragno, Antonello Mai and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. A Hypothesized Therapeutic Role of (Z)-Endoxifen in Duchenne Muscular Dystrophy (DMD).Degenerative neurological and neuromuscular disease · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jacopo MorroniDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Section of Histology and Embryology, Sapienza University of Rome, 00161 Rome, Italy.
Leonardo SchironeDepartment of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-7903-7660
Valentina ValentiDepartment of Cardiology, Ospedale Santa Maria Goretti, 04100 Latina, Italy.
Clemens ZwergelDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-3097-0003
Carles Sánchez RieraDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Section of Histology and Embryology, Sapienza University of Rome, 00161 Rome, Italy.
Sergio ValenteDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-2241-607X
Daniele VecchioDepartment of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-3859-6869
Sonia SchiavonDepartment of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00185 Rome, Italy.
Rino RagnoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-5399-975X
Antonello MaiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-9176-2382
Sebastiano SciarrettaDepartment of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00185 Rome, Italy.
Biliana Lozanoska-OchserDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Section of Histology and Embryology, Sapienza University of Rome, 00161 Rome, Italy.
Marina BouchèDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedic Sciences, Section of Histology and Embryology, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-0938-5360
Sapienza University of Rome · ITIstituto Neurologico Mediterraneo · ITOspedale Santa Maria Goretti · IT

Funding

Duchenne Parent Project, Italy BoucheSapienza University of Rome RM118164275C7EBESapienza University of Rome RM11916B7E20311CSapienza University of Rome RP11715C7D238352Sapienza University of Rome RP120172B32DE4C7
6 · The paper itself

Abstract

Chronic cardiac muscle inflammation and subsequent fibrotic tissue deposition are key features in Duchenne Muscular Dystrophy (DMD). The treatment of choice for delaying DMD progression both in skeletal and cardiac muscle are corticosteroids, supporting the notion that chronic inflammation in the heart plays a pivotal role in fibrosis deposition and subsequent cardiac dysfunction. Nevertheless, considering the adverse effects associated with long-term corticosteroid treatments, there is a need for novel anti-inflammatory therapies. In this study, we used our recently described

Indexed as

AnimalsCardiomyopathiesDipeptidesDisease Models, AnimalDystrophinFibrosisHeartInflammationMaleMiceMice, Inbred C57BLMice, Inbred mdxMuscle, SkeletalMuscular Dystrophy, AnimalMuscular Dystrophy, DuchenneMyocardiumcompound 20DipeptidesDystrophinProtein Kinase C-thetacardiomyopathyDMDinflammationPKCθ

Identifiers

PMID35216371
PMCPMC8880527
OpenAlexW4212798524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.