Evidence map›Paper›PMID 35216338›Full record

ArticleInternational journal of molecular sciences2022

Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel Na

Alican Gulsevin, Andrew M Glazer, Tiffany Shields, Brett M Kroncke, Dan M Roden, Jens Meiler

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Discovery of NaJournal of natural products · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. New Insights into Cardiac Ion Channel Regulation 2.0.International journal of molecular sciences · 2023
    Article
  10. Inhibitory Effects of Nobiletin on Voltage-Gated NaInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alican GulsevinDepartment of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37212, USA.ORCID 0000-0002-8724-5777
Andrew M GlazerDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-3938-4713
Tiffany ShieldsDepartment of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37212, USA.
Brett M KronckeDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Dan M RodenDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-6302-0389
Jens MeilerDepartment of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37212, USA.ORCID 0000-0001-8945-193X
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Structural basis for caveolae assembly and functionR01HL144131 · NHLBI · VANDERBILT UNIVERSITY · PI KENWORTHY, ANNE K, OHI, MELANIE DIANE · 2018 to 2021
$2.2M
Structural Determinants of Allosteric Modulation of Brain GPCRsR01DA046138 · NIDA · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2019 to 2023
$2.0M
SCN5A (Nav1.5): Predicting the Consequence of Missense Single- Nucleotide Polymorphisms.R00HL135442 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KRONCKE, BRETT M · 2019 to 2021
$741k
High-Performance Computer Cluster for Biomedical ResearchS10OD023680 · OD · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2017 to 2017
$587k
Nanion SynchroPatch 384 for Automated, High-throughput ElectrophysiologyS10OD025281 · OD · VANDERBILT UNIVERSITY · PI WEAVER, C DAVID · 2018 to 2018
$571k
Hybrid Methods for Prediction and Design of Novel Human Influenza AntibodiesR56AI110750 · NIAID · VANDERBILT UNIVERSITY · PI CROWE, JAMES E, MEILER, JENS · 2014 to 2014
$433k
A pipeline for identifying disease-causing variants in transmembrane proteinsK99HG010904 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, ANDREW M. · 2020 to 2021
$223k
NHGRI NIH HHS K99 HG010904NHLBI NIH HHS R00 HL135442NHLBI NIH HHS R01 HL144131NIAID NIH HHS R56 AI110750NIDA NIH HHS R01 DA046138NIH HHS S10 OD023680NIH HHS S10 OD025281
6 · The paper itself

Abstract

The cardiac sodium ion channel (Na

Indexed as

Binding SitesCell LineHEK293 CellsHumansIon Channel GatingMouthNAV1.5 Voltage-Gated Sodium ChannelNeurotoxinsSodiumVeratridineNAV1.5 Voltage-Gated Sodium ChannelNeurotoxinsSCN5A protein, humanSodiumVeratridinecardiac sodium channelselectrophysiologymolecular dockingRosettaSCN5Asite-directed mutagenesistoxinsveratridinevoltage-gated sodium channels

Identifiers

PMID35216338
PMCPMC8878851
OpenAlexW4220789546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.