Evidence map›Paper›PMID 35216297›Full record

ArticleInternational journal of molecular sciences2022

Design and Characterization of Myristoylated and Non-Myristoylated Peptides Effective against

Francesca Bugli, Federica Massaro, Francesco Buonocore, Paolo Roberto Saraceni, Stefano Borocci, Francesca Ceccacci, Cecilia Bombelli, Maura Di Vito, Rosalba Marchitiello, Melinda Mariotti and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Current Perspectives of Antifungal Therapy: A Special Focus onJournal of fungi (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Francesca BugliDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0001-9038-3233
Federica MassaroDepartment for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia, 01100 Viterbo, Italy.
Francesco BuonocoreDepartment for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0001-8045-5651
Paolo Roberto SaraceniDepartment for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0002-3225-0536
Stefano BorocciDepartment for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0003-4931-3019
Francesca CeccacciCNR-Institute For Biological Systems, Sede Secondaria di Roma-Meccanismi di Reazione, c/o Università La Sapienza, 00185 Rome, Italy.ORCID 0000-0003-3191-8562
Cecilia BombelliCNR-Institute For Biological Systems, Sede Secondaria di Roma-Meccanismi di Reazione, c/o Università La Sapienza, 00185 Rome, Italy.
Maura Di VitoDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0002-2991-0855
Rosalba MarchitielloDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Melinda MariottiDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Riccardo TorelliDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A, Gemelli IRCCS, 00168 Rome, Italy.
Maurizio SanguinettiDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0002-9780-7059
Fernando PorcelliDepartment for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia, 01100 Viterbo, Italy.ORCID 0000-0003-3209-0074

Funding

Regione Lazio A0375-2020-36557
6 · The paper itself

Abstract

The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigated the in vitro and in vivo antifungal activity of three short myristoylated and non-myristoylated peptides derived from a mutant of the AMP

Indexed as

Antifungal AgentsCandidaAnimalsBiofilmsCandida albicansHumansLarvaLipopeptidesMammalsMicrobial Sensitivity TestsAntifungal AgentsLipopeptidesantifungal activityin vivo infection controllipopeptidemyristoylation

Identifiers

PMID35216297
PMCPMC8875392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.