Evidence map›Paper›PMID 35216289›Full record

ArticleInternational journal of molecular sciences2022

The Association of Cholesterol Uptake and Synthesis with Histology and Genotype in Cortisol-Producing Adenoma (CPA).

Naoki Motomura, Yuto Yamazaki, Daiki Koga, Shogo Harashima, Xin Gao, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Naoki MotomuraDepartment of Pathology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Yuto YamazakiDepartment of Pathology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Daiki KogaDepartment of Pathology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Shogo HarashimaDepartment of Pathology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Xin GaoDepartment of Pathology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Yuta TezukaDivision of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.ORCID 0000-0003-1546-6949
Kei OmataDivision of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Yoshikiyo OnoDivision of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Ryo MorimotoDivision of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital, Sendai 980-8574, Japan.
Fumitoshi SatohDivision of Clinical Hypertension, Endocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Yasuhiro NakamuraDivision of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan.
Go Eun KwonMolecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, Korea.ORCID 0000-0001-9036-7356
Man Ho ChoiMolecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, Korea.
Akihiro ItoDepartment of Urology, Tohoku University School of Medicine, Sendai 980-8574, Japan.
Hironobu SasanoDepartment of Pathology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Tohoku University · JPKorea Institute of Science and Technology · KRTohoku Medical and Pharmaceutical University · JPTohoku University Hospital · JP

Funding

Ministry of Health, Labour, and Welfare, Japan 20FC1020
6 · The paper itself

Abstract

Cortisol-producing adenoma (CPA) is composed of clear and compact cells. Clear cells are lipid abundant, and compact ones lipid poor but associated with higher production of steroid hormones.

Indexed as

AdenomaCushing SyndromeCholesterol EstersGenotypeHumansHydrocortisoneCholesterol EstersHydrocortisonecholesterol uptakecortisol producing adenomaCushing’s syndromede novo synthesisHSLimmunohistochemistrymass spectrometryPRKACA

Identifiers

PMID35216289
PMCPMC8875534
OpenAlexW4213156219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.