Evidence map›Paper›PMID 35216249›Full record

ArticleInternational journal of molecular sciences2022

Silicon-Gold Nanoparticles Affect Wharton's Jelly Phenotype and Secretome during Tri-Lineage Differentiation.

Elena V Svirshchevskaya, Nina V Sharonova, Rimma A Poltavtseva, Mariya V Konovalova, Anton E Efimov, Anton A Popov, Svetlana V Sizova, Daria O Solovyeva, Ivan V Bogdanov, Vladimir A Oleinikov

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Elena V SvirshchevskayaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.ORCID 0000-0002-5647-9298
Nina V SharonovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.
Rimma A PoltavtsevaNational Medical Research Center of Obstetrics, Gynecology and Perinatology Named after Academician V. I. Kulakov of the Ministry of Health of the Russian Federation, 4 Oparina Str., 117997 Moscow, Russia.
Mariya V KonovalovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.ORCID 0000-0003-3923-6304
Anton E EfimovShumakov National Medical Research Center of Transplantology and Artificial Organs, 1 Schukinskaya Str., 123182 Moscow, Russia.
Anton A PopovInstitute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI, 31 Kashirskoe Sh., 115409 Moscow, Russia.ORCID 0000-0001-8902-0371
Svetlana V SizovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.ORCID 0000-0003-0846-4670
Daria O SolovyevaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.
Ivan V BogdanovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.ORCID 0000-0001-8887-2898
Vladimir A OleinikovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya Str., 117997 Moscow, Russia.
Institute of Bioorganic Chemistry · RUInstitute of Engineering Physics · RUNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation · RUV.I.Shumakov Federal Research Center of Transplantology and Artificial Organs · RU

Funding

Ministry of Health of the Russian Federation AAAA-A20-120022790039-1Ministry of Science and Higher Education of the Russian Federation 075-15-2020-773
6 · The paper itself

Abstract

Multiple studies have demonstrated that various nanoparticles (NPs) stimulate osteogenic differentiation of mesenchymal stem cells (MSCs) and inhibit adipogenic ones. The mechanisms of these effects are not determined. The aim of this paper was to estimate Wharton's Jelly MSCs phenotype and humoral factor production during tri-lineage differentiation per se and in the presence of silicon-gold NPs. Silicon (SiNPs), gold (AuNPs), and 10% Au-doped Si nanoparticles (SiAuNPs) were synthesized by laser ablation, characterized, and studied in MSC cultures before and during differentiation. Humoral factor production (

Indexed as

AdipogenesisAnimalsCD13 AntigensCell DifferentiationChondrogenesisFemaleGoldHumansMesenchymal Stem CellsMetal NanoparticlesPhenotypeSecretomeSiliconThy-1 AntigensVascular Endothelial Growth Factor AWharton JellyCD13 AntigensGoldSiliconThy-1 AntigensVascular Endothelial Growth Factor Aadipogenic differentiationcell phenotypechondrogenicG-CSGLuminexMSCosteogenicsilicon–gold nanoparticlessoluble factorsVEGFWharton’s jelly mesenchymal stem cells

Identifiers

PMID35216249
PMCPMC8874983
OpenAlexW4212942675

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.