Evidence map›Paper›PMID 35216229›Full record

ArticleInternational journal of molecular sciences2022

Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects.

Antonín Edr, Dominika Wrobel, Alena Krupková, Lucie Červenková Šťastná, Petra Cuřínová, Aleš Novák, Jan Malý, Jitka Kalasová, Jan Malý, Marek Malý and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Antonín EdrInstitute of Chemical Process Fundamentals of the CAS, v.v.i., Rozvojová 135, 16502 Prague, Czech Republic.ORCID 0000-0001-9400-5379
Dominika WrobelFaculty of Science, J.E. Purkyně University in Ústí nad Labem, Pasteurova 15, 40096 Ústí nad Labem, Czech Republic.ORCID 0000-0003-3920-9330
Alena KrupkováInstitute of Chemical Process Fundamentals of the CAS, v.v.i., Rozvojová 135, 16502 Prague, Czech Republic.ORCID 0000-0001-9428-6393
Lucie Červenková ŠťastnáInstitute of Chemical Process Fundamentals of the CAS, v.v.i., Rozvojová 135, 16502 Prague, Czech Republic.
Petra CuřínováInstitute of Chemical Process Fundamentals of the CAS, v.v.i., Rozvojová 135, 16502 Prague, Czech Republic.ORCID 0000-0001-8264-7032
Aleš NovákFaculty of Science, J.E. Purkyně University in Ústí nad Labem, Pasteurova 15, 40096 Ústí nad Labem, Czech Republic.
Jan MalýFaculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16828 Prague 6, Czech Republic.
Jitka KalasováFaculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16828 Prague 6, Czech Republic.
Jan MalýFaculty of Science, J.E. Purkyně University in Ústí nad Labem, Pasteurova 15, 40096 Ústí nad Labem, Czech Republic.
Marek MalýFaculty of Science, J.E. Purkyně University in Ústí nad Labem, Pasteurova 15, 40096 Ústí nad Labem, Czech Republic.
Tomáš StrašákInstitute of Chemical Process Fundamentals of the CAS, v.v.i., Rozvojová 135, 16502 Prague, Czech Republic.

Funding

Czech Science Foundation 20-21421SERDF/ESF CZ.02.1.01/0.0/0.0/17_048/0007411European Cooperation in Science and Technology CA17140Ministry of Education, Youth and Sports of the Czech Republic COST LTC19049Ministry of Education, Youth and Sports of the Czech Republic CZ.02.1.01/0.0/0.0/16_013/0001821Ministry of Education, Youth and Sports of the Czech Republic LM2018124
6 · The paper itself

Abstract

Supramolecular structures, such as micelles, liposomes, polymerosomes or dendrimerosomes, are widely studied and used as drug delivery systems. The behavior of amphiphilic building blocks strongly depends on their spatial distribution and shape of polar and nonpolar component. This report is focused on the development of new versatile synthetic protocols for amphiphilic carbosilane dendrons (amp-CS-DDNs) capable of self-assembly to regular micelles and other supramolecular objects. The presented strategy enables the fine modification of amphiphilic structure in several ways and also enables the facile connection of a desired functionality. DLS experiments demonstrated correlations between structural parameters of amp-CS-DDNs and the size of formed nanoparticles. For detailed information about the organization and spatial distribution of amp-CS-DDNs assemblies, computer simulation models were studied by using molecular dynamics in explicit water.

Indexed as

AnthracenesComputer SimulationHydrophobic and Hydrophilic InteractionsMicellesNanoparticlesSilanesWaterAnthracenescarbosilanedendronMicellesSilanesWateramphiphilescarbosilanecomputer modelingdendronsDLSmicellesmolecular dynamicszeta potential

Identifiers

PMID35216229
PMCPMC8877797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.