Evidence map›Paper›PMID 35216180›Full record

ArticleInternational journal of molecular sciences2022

Anti-Septic Functions of Cornuside against HMGB1-Mediated Severe Inflammatory Responses.

Nayeon Kim, Chaeyeong Kim, Soo Ho Ryu, Wonhwa Lee, Jong-Sup Bae

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nayeon KimCollege of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University 80 Daehak-ro, Buk-gu, Daegu 41566, Korea.
Chaeyeong KimCollege of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University 80 Daehak-ro, Buk-gu, Daegu 41566, Korea.
Soo Ho RyuCollege of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University 80 Daehak-ro, Buk-gu, Daegu 41566, Korea.
Wonhwa LeeDepartment of Chemistry, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Korea.
Jong-Sup BaeCollege of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University 80 Daehak-ro, Buk-gu, Daegu 41566, Korea.ORCID 0000-0002-5756-9367
Kyungpook National University · KRSungkyunkwan University · KR

Funding

Korea Health Technology R&D Project through the Korea Health Industry Development Insti-tute, funded by the Ministry of Health & Welfare, Republic of Korea HI15C0001National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) 2020R1A2C1004131
6 · The paper itself

Abstract

High mobility group box 1 (HMGB1) is acknowledged to have critical functions; therefore, targeting this protein may have therapeutic effects. One example is potential antiseptic activity obtained by suppressing HMGB1 secretion, leading to the recovery of vascular barrier integrity. Cornuside (CN), which is a product extracted from the fruit of

Indexed as

AnimalsCell AdhesionCell MovementCells, CulturedCytokinesDisease Models, AnimalGlucosidesHMGB1 ProteinHumansHuman Umbilical Vein Endothelial CellsInflammationMaleMiceMice, Inbred C57BLPyransSepsiscornusideCytokinesGlucosidesHMGB1 ProteinHMGB1 protein, humanPyranscornusideendotheliumHMGB1sepsis

Identifiers

PMID35216180
PMCPMC8874448
OpenAlexW4213333499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.