Evidence map›Paper›PMID 35216152›Full record

ArticleInternational journal of molecular sciences2022

Tceal5 and Tceal7 Function in C2C12 Myogenic Differentiation via Exosomes in Fetal Bovine Serum.

Aika Sawada, Takuya Yamamoto, Takahiko Sato

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aika SawadaFaculty of Medical Sciences, Fujita Health University, Toyoake 470-1192, Japan.
Takuya YamamotoCenter for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.
Takahiko SatoFaculty of Medicine, Department of Anatomy, Fujita Health University, Toyoake 470-1192, Japan.ORCID 0000-0003-3836-7978

Funding

Japan Agency for Medical Research and Development JP20gm0810009Japan Society for the Promotion of Science 17K01859Nakatomi Foundation 2019
6 · The paper itself

Abstract

The proliferation and differentiation of skeletal muscle cells are usually controlled by serum components. Myogenic differentiation is induced by a reduction of serum components in vitro. It has been recently reported that serum contains not only various growth factors with specific actions on the proliferation and differentiation of myogenic cells, but also exogenous exosomes, the function of which is poorly understood in myogenesis. We have found that exosomes in fetal bovine serum are capable of exerting an inhibitive effect on the differentiation of C2C12 myogenic cells in vitro. In this process of inhibition, the downregulation of

Indexed as

Cell DifferentiationMyoblastsTranscription FactorsAnimalsCell LineExosomesMiceNuclear ProteinsSerum Albumin, BovineNuclear ProteinsSerum Albumin, BovineTceal5 protein, mouseTCEAL7 protein, mouseTranscription Factorsexosomemyogenic differentiationserumTceal5Tceal7

Identifiers

PMID35216152
PMCPMC8877866

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.