Evidence map›Paper›PMID 35216100›Full record

ArticleInternational journal of molecular sciences2022

Dysregulation of S-adenosylmethionine Metabolism in Nonalcoholic Steatohepatitis Leads to Polyamine Flux and Oxidative Stress.

Connor Quinn, Mario C Rico, Carmen Merali, Salim Merali

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Connor QuinnDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19122, USA.
Mario C RicoDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19122, USA.
Carmen MeraliDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19122, USA.
Salim MeraliDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19122, USA.
Temple University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease worldwide, with 25% of these patients developing nonalcoholic steatohepatitis (NASH). NASH significantly increases the risk of cirrhosis and decompensated liver failure. Past studies in rodent models have shown that glycine-

Indexed as

AdultAnimalsCarcinoma, HepatocellularDisease Models, AnimalFemaleGlycine N-MethyltransferaseHumansLiverLiver CirrhosisLiver NeoplasmsMaleMiceMiddle AgedNon-alcoholic Fatty Liver DiseaseOxidation-ReductionOxidative StressGlycine N-MethyltransferasePolyaminesS-Adenosylmethionineglycine-N-methyl transferasenonalcoholic steatohepatitispolyaminesS-adenosylmethionine

Identifiers

PMID35216100
PMCPMC8878801
OpenAlexW4211145805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.