Evidence map›Paper›PMID 35216068›Full record

ReviewInternational journal of molecular sciences2022

Ion Channel Partnerships: Odd and Not-So-Odd Couples Controlling Neuronal Ion Channel Function.

Nicholas C Vierra, James S Trimmer

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. The Electrically Silent Kv5.1 Subunit Forms Heteromeric Kv2 Channels in Cortical Neurons and Confers Distinct Functional Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Review
  5. Calcium-Dependent Regulation of Neuronal Excitability Is Rescued in Fragile X Syndrome by a Tat-Conjugated N-Terminal Fragment of FMRP.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Watching Ion Channels on the Move.Function (Oxford, England) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nicholas C VierraDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA 95616, USA.
James S TrimmerDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA 95616, USA.ORCID 0000-0002-6117-3912
University of California, Davis · US

Funding

Neuronal Kv2.1 Potassium Channels as Organizers of Somatic L-Type Calcium Channel MicrodomainsR01NS114210 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DICKSON, EAMONN JAMES, SANTANA, LUIS F · 2020 to 2024
$2.3M
Tuning L-Type Ca Channel Activity in Arterial Smooth Muscle by Kv Channel-Mediated ClusteringR01HL144071 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SANTANA, LUIS F, TRIMMER, JAMES S · 2018 to 2021
$2.0M
Dynamic modulation of ionic and lipid signaling by neuronal Kv2 channelsF32NS108519 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VIERRA, NICHOLAS CATIN · 2018 to 2020
$168k
NHLBI NIH HHS R01 HL144071NIH HHS F32NS108519NIH HHS R01HL144071NIH HHS R01NS114210NINDS NIH HHS R01 NS114210
6 · The paper itself

Abstract

The concerted function of the large number of ion channels expressed in excitable cells, including brain neurons, shapes diverse signaling events by controlling the electrical properties of membranes. It has long been recognized that specific groups of ion channels are functionally coupled in mediating ionic fluxes that impact membrane potential, and that these changes in membrane potential impact ion channel gating. Recent studies have identified distinct sets of ion channels that can also physically and functionally associate to regulate the function of either ion channel partner beyond that afforded by changes in membrane potential alone. Here, we review canonical examples of such ion channel partnerships, in which a Ca

Indexed as

AnimalsCalciumIon Channel GatingIon ChannelsMembrane PotentialsNeuronsPotassiumSignal TransductionCalciumIon ChannelsPotassiumcalcium signalingion channelsneuronsprotein–protein interaction

Identifiers

PMID35216068
PMCPMC8878034
OpenAlexW4211085230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.