ReviewInternational journal of molecular sciences2022
Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy.
Open access · goldAbstract readReview
In one paragraph
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 38 citations in OpenAlex.
- VCP at the crossroads of UPS and autophagy in cancer.Genes & diseases · 2027Review
- Organelle contact reorganization drives calcium-dependent autophagy under proteostatic stress.Autophagy · 2026Article
- Inclusion-Body Myopathy with Paget Disease of the Bone and Frontotemporal Dementia (IBMPFD) withDiagnostics (Basel, Switzerland) · 2026Article
- A Pyrazole-Based Small Molecule, KB3409, Restores Mitochondrial Function via VCP Activation and RCN2-Dependent CaAntioxidants (Basel, Switzerland) · 2026Article
- Nucleophagy removes cytotoxic trapped PARP1.Nature cell biology · 2026Article
- Gene Expression Analysis of Mitochondria-Associated Membrane (MAM)-Related Genes in ER Stress and Alzheimer's Disease.Cellular and molecular neurobiology · 2026Article
- VCP modulation ameliorates pathological features in C9orf72 models.Cell death & disease · 2026Article
- Targeting VCP with V8 suppresses glioblastoma development via formation of aggregates and disruption of mitophagy flux.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies.Frontiers in cellular neuroscience · 2026Review
- Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders.Autophagy · 2026Review
- Mutual reinforcement of lymphotoxin-driven myositis and impaired autophagy in murine muscle.Brain : a journal of neurology · 2025Article
- Targeting VCP enhances colorectal cancer therapy through STING stabilization.Journal for immunotherapy of cancer · 2025Article
- Ubiquitin-specific proteases as key regulators in the malignant progression and therapy resistance of colorectal cancer: current insights and future perspectives.Discover oncology · 2025Review
- The Proteostasis Network in Proteinopathies: Mechanisms and Interconnections.The American journal of pathology · 2025Review
- The connection between autophagy and Alzheimer's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- An ethanol-induced loss of the lipid droplet-associated segregase VCP/p97 leads to hepatic steatosis.The Journal of cell biology · 2025Article
- Exploring the multilayered response of TB bacterium Mycobacterial tuberculosis to lysosomal injury.FEMS microbiology reviews · 2025Review
- A guide to selecting high-performing antibodies for VCP (UniProt ID: P55072) for use in western blot, immunoprecipitation, and immunofluorescence.F1000Research · 2025Article
- Loss of function of VCP/TER94 causes neurodegeneration.Disease models & mechanisms · 2024Article
- Dominantly inherited muscle disorders: understanding their complexity and exploring therapeutic approaches.Disease models & mechanisms · 2024Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Veronica FerrariDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.ORCID 0000-0003-2514-9445
Riccardo CristofaniDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.ORCID 0000-0003-2719-846X
Barbara TedescoUnit of Medical Genetics and Neurogenetics, Fondazione IRCCS-Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Valeria CrippaDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.ORCID 0000-0002-3058-5711
Marta ChierichettiDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.ORCID 0000-0003-0549-0742
Elena CasarottoDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.ORCID 0000-0002-3842-8243
Marta CozziDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.ORCID 0000-0001-9428-7054
Francesco MinaDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.
Margherita PiccolellaDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.ORCID 0000-0002-5130-1116
Mariarita GalbiatiDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.ORCID 0000-0003-3250-5591
Paola RusminiDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.ORCID 0000-0001-9989-0733
Angelo PolettiDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.ORCID 0000-0002-8883-0468
University of Milan · ITFondazione IRCCS Istituto Neurologico Carlo Besta · IT
Funding
EU Joint Programme-Neurodegenerative Disease Research (JPND) 01ED1601A, CureALSFondazione Cariplo 2014-0686Fondazione Cariplo 2017-0747Fondazione Cariplo 2021-1544Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica ALS_GranulopathyFondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica ALS_HSPB8Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica MLOpathyFondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica Target-RANFondazione regionale per la ricerca Biomedica (FRRB) TRANS_ALS, project nr. 2015-0023French Muscular Dystrophy Association 23236Italian Medicines Agency Co_ALSMinistry of Education, Universities and Research 2015LFPNMNMinistry of Education, Universities and Research 2017F2A2C5Ministry of Education, Universities and Research 2020PBS5MJMinistry of Education, Universities and Research Fondo per il Finanziamento delle Attività Base di Ricerca (FFABR)Telethon Foundation GGP14039Telethon Foundation GGP19128University of Milan piano di sviluppo UNIMI - linea BUniversity of Milan SEED 2019: #Gender-ALSUniversity of Milan SEED 2019: #TDP-43-iPSC
Abstract
Valosin containing protein (VCP) has emerged as a central protein in the regulation of the protein quality control (PQC) system.
Indexed as
AnimalsAutophagyHumansNeurodegenerative DiseasesNeuronsProteostasisValosin Containing ProteinValosin Containing Proteinautophagylysophagyneurodegenerative diseaseNF-κBTFE3TFEBVCP
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.