Evidence map›Paper›PMID 35215995›Full record

ArticleViruses2022

Ergosterol Peroxide Inhibits Porcine Epidemic Diarrhea Virus Infection in Vero Cells by Suppressing ROS Generation and p53 Activation.

Yi Liu, Xue Wang, Jing Wang, Jialu Zhang, Cong Duan, Jiufeng Wang

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
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  5. Article
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  8. Article
  9. Haplotype-Phased Chromosome-Level Genome Assembly ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Licorice extract inhibits porcine epidemic diarrhea virusThe Journal of general virology · 2024
    Article
  14. The Culprit Behind HBV-Infected Hepatocytes: NTCP.Drug design, development and therapy · 2024
    Review
  15. Roles of p53-Mediated Host-Virus Interaction in Coronavirus Infection.International journal of molecular sciences · 2023
    Review
  16. In silico andFrontiers in cellular and infection microbiology · 2023
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yi LiuCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Xue WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Jing WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Jialu ZhangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Cong DuanChina Institute of Veterinary Drug Control, Beijing 100193, China.
Jiufeng WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-0183-5611
China Agricultural University · CNChina Institute of Veterinary Drug Control · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus that causes severe watery diarrhea in piglets with high morbidity and mortality, resulting in serious economic losses to the farming industry. Ergosterol peroxide (EP) is a sterol with diverse biological activities including antiviral activity. In this study, we explored whether EP extracted from the fruiting body of the mushroom

Indexed as

AnimalsApoptosisChlorocebus aethiopsCoronavirus InfectionsErgosterolPolyporaceaePorcine epidemic diarrhea virusReactive Oxygen SpeciesSwineSwine DiseasesTumor Suppressor Protein p53Vero CellsVirus ReplicationErgosterolergosterol-5,8-peroxideReactive Oxygen SpeciesTumor Suppressor Protein p53apoptosisergosterol peroxidelife cyclep53porcine epidemic diarrhea virusROS

Identifiers

PMID35215995
PMCPMC8876155
OpenAlexW4213054935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.