Evidence map›Paper›PMID 35215980›Full record

ArticleViruses2022

A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines.

Naru Zhang, Kangchen Li, Zezhong Liu, Kutty Selva Nandakumar, Shibo Jiang

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Article
  3. Hybrid response to SARS-CoV-2 andHuman vaccines & immunotherapeutics · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. COVID-19 Vaccines, Effectiveness, and Immune Responses.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Naru ZhangDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China.ORCID 0000-0002-8906-1453
Kangchen LiDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China.ORCID 0000-0001-5523-5841
Zezhong LiuKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.
Kutty Selva NandakumarDepartment of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden.ORCID 0000-0001-7790-8197
Shibo JiangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.ORCID 0000-0001-8283-7135
Fudan University · CNKarolinska Institutet · SE

Funding

National Natural Science Foundation of China 82041025 and 92169112Scientific Research Foundation of Zhejiang University City College J-202106
6 · The paper itself

Abstract

Several countries have made unremitting efforts to develop an optimal vaccine in the fight against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the increasing occurrence of SARS-CoV-2 variants, current vaccines show decreased neutralizing activities, especially towards the Omicron variant. In this context, adding appropriate adjuvants to COVID-19 vaccines can substantially reduce the number of required doses and improve efficacy or cross-neutralizing protection. We mainly focus on research progress and achievements associated with adjuvanted COVID-19 subunit and inactivated vaccines. We further compare the advantages and disadvantages of different adjuvant formulations in order to provide a scientific reference for designing an effective strategy for future vaccine development.

Indexed as

Adjuvants, ImmunologicAntibodies, NeutralizingAntibodies, ViralCOVID-19COVID-19 VaccinesHumansSARS-CoV-2Vaccine DevelopmentVaccines, InactivatedAdjuvants, ImmunologicAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesVaccines, InactivatedadjuvantCOVID-19SARS-CoV-2vaccinevariants

Identifiers

PMID35215980
PMCPMC8875727
OpenAlexW4213069943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.