ArticleViruses2022
Cytomegalovirus Diseases of the Gastrointestinal Tract.
Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chronic Gastric Ulceration Due to Cytomegalovirus in Immunocompetent Adults - A Case Report and Systematic Review.Reviews in medical virology · 2026Pooled it
- Tissue Cytomegalovirus DNA Detection by PCR Is Associated with Increased Endoscopic Activity in Ulcerative Colitis: A Retrospective Cohort Study.Biomedicines · 2026Article
- Cytomegalovirus enteritis as an unusual cause of small bowel obstruction in an immunocompetent woman: a case report.Journal of surgical case reports · 2026Article
- Cytomegalovirus Enteritis after Surgery for Acute Type A Aortic Dissection Complicated by Malperfusion and Thymoma: A Case Report.Surgical case reports · 2026Article
- Is It Possible to Determine Plasma Cytomegalovirus DNA Cut-off and Develop a Scoring System to Predict Cytomegalovirus Gastrointestinal Disease?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Article
- Cytomegalovirus-induced Oral, Esophageal, Gastric and Colonic Ulcers in an Immunocompetent Patient.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Article
- Gastrointestinal cytomegalovirus infection in persons with HIV: a retrospective case series study.BMC infectious diseases · 2025Article
- Immune reconstitution of human cytomegalovirus-specific T lymphocytes after allogeneic hematopoietic stem cell transplantation and their predictive role in reactivation.Frontiers in immunology · 2025Article
- Ogilvie's Syndrome Following Herpes Zoster Infection: A Comprehensive Review of the Literature.Cureus · 2024Review
- Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024Review
- The Wide Spectrum of Presentations of Cytomegalovirus Infection in Immunocompetent Hosts: An Exhaustive Narrative Review.Pathogens (Basel, Switzerland) · 2024Review
- Good's syndrome combined with CMV gastroenteritis: A case report and literature review.Clinical case reports · 2024Article
- Article
- Adequate antiviral treatment lowers overall complications of cytomegalovirus colitis among inpatients with inflammatory bowel diseases.BMC infectious diseases · 2024Article
- Comparative Analysis of Cytomegalovirus Gastrointestinal Disease in Immunocompetent and Immunocompromised Patients.Viruses · 2024Article
- Cytomegalovirus Diseases of the Gastrointestinal Tract in Immunocompetent Patients: A Narrative Review.Viruses · 2024Review
- Coinfection of cytomegalovirus and strongyloidiasis presenting as massive gastrointestinal bleeding in an immunocompromised host: a case report.Frontiers in medicine · 2024Article
- Case of Pseudomembranous Colitis Caused by aThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2023Article
- Immunohistochemistry Staining-Proven Cytomegalovirus Colitis in Living Donor Liver Transplantation.Viruses · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytomegalovirus (CMV) infection of the gastrointestinal (GI) tract can be fatal. However, very few studies have provided comprehensive analyses and specified the differences in symptoms observed in different parts of the GI tract. This study aimed to comprehensively analyze clinical manifestations and management of GI CMV disease. This retrospective cohort study enrolled the patients who had CMV diseases of the GI tract proved by CMV immunohistochemistry stain from the pathology database in a 4000-bed tertiary medical center between January 2000 and May 2021. The patient characteristics, clinical manifestations, endoscopic features, treatments, outcomes, and prognostic factors were analyzed. A total of 356 patients were enrolled, including 46 infected in the esophagus, 76 in the stomach, 30 in the small intestine, and 204 in the colon. In total, 49.4% patients were immunocompromised. The overall in-hospital mortality rate was 20.8%: CMV enteritis had the highest rate (23.3%). Sixty percent of patients received antiviral treatment and 16% were administered both intravenous and oral anti-viral drugs (Combo therapy, minimal and mean treatment duration were 14 and 39.9 ± 25 days). Prognostic factors of in-hospital mortality included age, immune status, albumin level, platelet count, GI bleeding, time-to-diagnosis, and Combo therapy. In the survival analysis, immunocompetent patients receiving Combo therapy had the best survival curve, and immunocompromised patients receiving non-Combo therapy had the worst survival curve. Combo therapy ≥14 days resulted in a better outcome for both immunocompromised and immunocompetent patients. In conclusion, CMV GI diseases affect both immunocompromised and immunocompetent hosts, and a complete treatment course should be considered for patients with poor prognostic factors.
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