ArticleViruses2022
Isolation, Characterization, and Molecular Detection of Porcine Sapelovirus.
Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 13 citations in OpenAlex.
- The Emergence and Evolution of Porcine Sapelovirus: Insights from Genomic Surveillance and Recombination Analysis in China.Viruses · 2026Article
- Emergence of a Novel Highly Pathogenic Recombinant RNA Virus of Picornaviridae with Blood-Brain Barrier Breaching Capability in China.Animals : an open access journal from MDPI · 2026Article
- Article
- Fecal metatranscriptomics and virus isolation reveal picornavirus diversity and evolution in Japanese wild boars and pigs.Scientific reports · 2026Article
- Pig Genome Editing for Agriculture: Achievements and Challenges.International journal of molecular sciences · 2025Review
- Prevalence and VP1 Gene Evaluation Analysis of Porcine Sapelovirus in Yunnan Province, China, from 2024 to 2025.Viruses · 2025Article
- Seroprevalence, Genetic Characteristics, and Pathogenicity of Korean Porcine Sapeloviruses.Viruses · 2025Article
- First Isolation and Characterization of Three Strains of Porcine Sapelovirus in Yunnan Province, China.Viruses · 2025Article
- A Quadruplex RT-qPCR for the Detection of Porcine Sapelovirus, Porcine Kobuvirus, Porcine Teschovirus, and Porcine Enterovirus G.Animals : an open access journal from MDPI · 2025Article
- Emergence of two novel viruses in Tibetan pigs with porcine diarrheal disease on the Tibetan plateau of southwest China.Frontiers in veterinary science · 2025Article
- Rapid detection of porcine sapelovirus by reverse transcription recombinase polymerase amplification assay.Molecular biology reports · 2024Article
- Development of an indirect ELISA method based on the VP1 protein for detection of IgG antibodies against porcine sapelovirus.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Isolation and Characterization of Porcine Sapelovirus from the PDCoV-Positive Sample and Its Molecular Epidemiology in Henan Province, China.Transboundary and emerging diseases · 2023Article
- Structural diversity and biological role of the 5' untranslated regions of picornavirus.RNA biology · 2023Review
- Virome Analysis for Identification of a Novel Porcine Sapelovirus Isolated in Western China.Microbiology spectrum · 2022Article
- Porcine sapelovirus 2A protein induces mitochondrial-dependent apoptosis.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine sapelovirus (PSV) is an important emerging pathogen associated with a wide variety of diseases in swine, including acute diarrhoea, respiratory distress, skin lesions, severe neurological disorders, and reproductive failure. Although PSV is widespread, serological assays for field-based epidemiological studies are not yet available. Here, four PSV strains were recovered from diarrheic piglets, and electron microscopy revealed virus particles with a diameter of ~32 nm. Analysis of the entire genome sequence revealed that the genomes of PSV isolates ranged 7569-7572 nucleotides in length. Phylogenetic analysis showed that the isolated viruses were classified together with strains from China. Additionally, monoclonal antibodies for the recombinant PSV-VP1 protein were developed to specifically detect PSV infection in cells, and we demonstrated that isolated PSVs could only replicate in cells of porcine origin. Using recombinant PSV-VP1 protein as the coating antigen, we developed an indirect ELISA for the first time for the detection of PSV antibodies in serum. A total of 516 swine serum samples were tested, and PSV positive rate was 79.3%. The virus isolates, monoclonal antibodies and indirect ELISA developed would be useful for further understanding the pathophysiology of PSV, developing new diagnostic assays, and investigating the epidemiology of the PSV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.