Evidence map›Paper›PMID 35215921›Full record

ArticleViruses2022

Carbohydrate Ligands for COVID-19 Spike Proteins.

Yung-Kuo Lee, Wen-Chiu Chang, Ekambaranellore Prakash, Yu-Ju Peng, Zhi-Jay Tu, Chun-Hung Lin, Pang-Hung Hsu, Chuan-Fa Chang

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Yung-Kuo LeeDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0003-1638-8049
Wen-Chiu ChangBlood Bank, Department of Pathology, National Cheng Kung University Hospital, No. 138, Sheng Li Road, Tainan 704, Taiwan.
Ekambaranellore PrakashIndus Biotech Private Limited, Kondhwa, Pune 411048, India.
Yu-Ju PengDepartment of Chemistry, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0001-7352-5746
Zhi-Jay TuInstitute of Biological Chemistry, Academia Sinica, No. 128 Academia Road Section 2, Nan-Kang, Taipei 11529, Taiwan.ORCID 0000-0002-3531-9439
Chun-Hung LinDepartment of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
Pang-Hung HsuDepartment of Bioscience and Biotechnology, National Taiwan Ocean University, No. 2, Beining Rd., Keelung 20224, Taiwan.ORCID 0000-0001-6873-6434
Chuan-Fa ChangDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
National Taiwan University · TWIndus Biotech (India) · INInstitute of Biological Chemistry, Academia Sinica · TWKaohsiung Armed Forces General Hospital · TWNational Cheng Kung University · TWNational Cheng Kung University Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

Ministry of Science and Technology, Taipei, Taiwan MOST 107-2320-B-006-028 and MOST 108-2320-B-006-042
6 · The paper itself

Abstract

An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic has caused more than 340 million confirmed cases and 5.57 million deaths as of 23 January 2022. Although carbohydrates have been found to play a role in coronavirus binding and infection, the role of cell surface glycans in SARS-CoV-2 infection and pathogenesis is still not understood. Herein, we report that the SARS-CoV-2 spike protein S1 subunit binds specifically to blood group A and B antigens, and that the spike protein S2 subunit has a binding preference for Le

Indexed as

CarbohydratesChinaCOVID-19ErythrocytesHumansLigandsPolysaccharidesProtein Array AnalysisProtein BindingSARS-CoV-2Spike Glycoprotein, CoronavirusVirus InternalizationCarbohydratesLigandsPolysaccharidesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2blood groupcarbohydrate ligandCOVID-19spike protein

Identifiers

PMID35215921
PMCPMC8880561
OpenAlexW4210297139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.