Evidence map›Paper›PMID 35215907›Full record

ArticleViruses2022

Human SUMOylation Pathway Is Critical for Influenza B Virus.

Runrui Dang, Victor G J Rodgers, Adolfo García-Sastre, Jiayu Liao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Runrui DangDepartment of Bioengineering, Institute for Integrative Genome Biology, School of Medicine, College of Engineering, Biomedical Science, University of California at Riverside, 900 University Avenue, Riverside, CA 92521, USA.
Victor G J RodgersDepartment of Bioengineering, Institute for Integrative Genome Biology, School of Medicine, College of Engineering, Biomedical Science, University of California at Riverside, 900 University Avenue, Riverside, CA 92521, USA.
Adolfo García-SastreDepartment of Microbiology, Global Health and Emerging Pathogens Institute, 1468 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0002-6551-1827
Jiayu LiaoDepartment of Bioengineering, Institute for Integrative Genome Biology, School of Medicine, College of Engineering, Biomedical Science, University of California at Riverside, 900 University Avenue, Riverside, CA 92521, USA.ORCID 0000-0002-2624-5781
University of California, Riverside · USNew York University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The identification and elucidation of host pathways for viral infection are critical for understanding the viral infection processes and novel therapeutics development. Here, for the first time, we discover that the human SUMOylation pathway is essential for the IBV viral life cycle. First, IBV viruses were completely inhibited by a novel SUMOylation specific inhibitor, STE025, discovered from our FRET-based high-throughput screening, and the inhibition was very potent, with IC

Indexed as

SumoylationCell LineHost-Pathogen InteractionsHumansInfluenza B virusInfluenza, HumanUbiquitin-Protein LigasesViral Matrix ProteinsVirus ReplicationUbiquitin-Protein LigasesViral Matrix Proteinscritical host factorinfluenza B virus or IBVSUMOylationtherapeutics

Identifiers

PMID35215907
PMCPMC8876058
OpenAlexW4210729780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.