Evidence map›Paper›PMID 35215901›Full record

ArticleViruses2022

Hepatitis C Screening and Treatment Program in Hungarian Prisons in the Era of Direct Acting Antiviral Agents.

Klára Werling, Béla Hunyady, Mihály Makara, Krisztina Nemesi, Gábor Horváth, Ferenc Schneider, Judit Enyedi, Zsófia Müller, Miklós Lesch, Zoltán Péterfi and 6 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Klára WerlingDepartment of Surgery, Transplantation and Gastroenterology, Semmelweis University, 1082 Budapest, Hungary.
Béla HunyadyDepartment of Gastroenterology, Somogy County Kaposi Mór Teaching Hospital, 7400 Kaposvár, Hungary.
Mihály MakaraNational Institute of Hematology and Infectious Diseases, Szent László Site, South-Pest Central Hospital, 1097 Budapest, Hungary.
Krisztina NemesiNational Institute of Hematology and Infectious Diseases, Szent László Site, South-Pest Central Hospital, 1097 Budapest, Hungary.
Gábor HorváthHepatology Center of Buda, 1111 Budapest, Hungary.
Ferenc SchneiderDepartment of Infectology, Markusovszky University Teaching Hospital, 9700 Szombathely, Hungary.ORCID 0000-0003-0610-5308
Judit EnyediDepartment of Infectology, Markhot Ferenc Teaching Hospital and Clinic, 3300 Eger, Hungary.
Zsófia MüllerDepartment of Infectology, Szent György University Teaching Hospital of County Fejér, 8000 Székesfehérvár, Hungary.
Miklós LeschDepartment of Infectology, Szabolcs-Szatmár-Bereg County Hospitals Jósa András Teaching Hospital, 4412 Nyíregyháza, Hungary.
Zoltán PéterfiFirst Department of Internal Medicine, Clinical Center, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0001-9658-153X
Tamás TóthDepartment of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary.
Judit GácsNational Institute of Hematology and Infectious Diseases, Szent László Site, South-Pest Central Hospital, 1097 Budapest, Hungary.
Zsuzsanna FehérDepartment of Infectology, Markusovszky University Teaching Hospital, 9700 Szombathely, Hungary.
Eszter UjhelyiMikromikomed Ltd., 1036 Budapest, Hungary.
Emese MolnárDepartment of Transfusiology, Semmelweis University, 1089 Budapest, Hungary.
Anna Nemes NagyDepartment of Health, Hungarian Prison Services, 1054 Budapest, Hungary.
Semmelweis University · HUUnified Szent István and Szent László Hospital · HUMarkusovszky Egyetemi Oktatókórház · HUBuda Health Center · HUFejér Megyei Szent György Egyetemi Oktató Kórház · HUJahn Ferenc Dél-Pesti Kórház és Rendelőintézet · HUJósa András Múzeum · HUSomogy Megyei Kaposi Mór Oktató Kórház · HUUniversity of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A hepatitis C virus (HCV) screening and treatment program was conducted in Hungarian prisons on a voluntary basis. After HCV-RNA testing and genotyping for anti-HCV positives, treatments with direct-acting antiviral agents were commenced by hepatologists who visited the institutions monthly. Patients were supervised by the prisons' medical staff. Data were retrospectively collected from the Hungarian Hepatitis Treatment Registry, from the Health Registry of Prisons, and from participating hepatologists. Eighty-four percent of Hungarian prisons participated, meaning a total of 5779 individuals (28% of the inmate population) underwent screening. HCV-RNA positivity was confirmed in 317/5779 cases (5.49%); 261/317 (82.3%) started treatment. Ninety-nine percent of them admitted previous intravenous drug use. So far, 220 patients received full treatment and 41 patients are still on treatment. Based on the available end of treatment (EOT) + 24 weeks timepoint data, per protocol sustained virologic response rate was 96.8%. In conclusion, the Hungarian prison screening and treatment program, with the active participation of hepatologists and the prisons' medical staff, is a well-functioning model. Through the Hungarian experience, we emphasize that the "test-and-treat" principle is feasible and effective at micro-eliminating HCV in prisons, where infection rate, as well as history of intravenous drug usage, are high.

Indexed as

AdolescentAdultAntiviral AgentsFemaleHepacivirusHepatitis CHumansHungaryMaleMass ScreeningMiddle AgedPrisonsRetrospective StudiesSustained Virologic ResponseYoung AdultAntiviral Agentsdrug usersharm reductionhepatitis CHungaryinmatesprisonsscreeningtreatment

Identifiers

PMID35215901
PMCPMC8876701
OpenAlexW4210591218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.