Evidence map›Paper›PMID 35215771›Full record

ArticleViruses2022

Venous Thrombosis within 30 Days after Vaccination against SARS-CoV-2 in a Multinational Venous Thromboembolism Registry.

Behnood Bikdeli, David Jiménez, Pablo Demelo-Rodriguez, Francisco Galeano-Valle, José Antonio Porras, Raquel Barba, Cihan Ay, Radovan Malý, Andrei Braester, Egidio Imbalzano and 7 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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  13. Special Issue "COVID-19 and Venous Thromboembolism".Journal of clinical medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 15 institutions in 6 countries.

Behnood BikdeliCardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David JiménezRespiratory Department, Hospital Ramón y Cajal and Universidad de Alcalá (IRYCIS), 28034 Madrid, Spain.ORCID 0000-0002-4571-7721
Pablo Demelo-RodriguezDepartment of Internal Medicine, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0002-3096-4711
Francisco Galeano-ValleDepartment of Internal Medicine, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0003-1321-6866
José Antonio PorrasDepartment of Internal Medicine, Hospital Universitario Joan XXIII de Tarragona, 43005 Tarragona, Spain.
Raquel BarbaDepartment of Internal Medicine, Hospital Rey Juan Carlos, 28933 Madrid, Spain.
Cihan AyDepartment of Medicine I - Clinical Division of Haematology and Haemostaseology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-2607-9717
Radovan MalýDepartment of Cardiovascular Medicine I, Faculty of Medicine, Charles University in Prague, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0002-9199-7883
Andrei BraesterDepartment of Haematology, Azrieli Faculty of Medicine, Bar-Ilan University, 13195 Safed, Israel.
Egidio ImbalzanoDepartment of Clinical and Experimental Medicine, A.O.U Policlinico "G. Martino", 98124 Messina, Italy.ORCID 0000-0003-2656-5467
Vladimir RosaDepartment of Internal Medicine, Hospital Universitario Virgen de Arrixaca, 30120 Murcia, Spain.ORCID 0000-0001-5039-6638
Ramón LecumberriDepartment of Haematology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Carmine SiniscalchiDepartment of Angiology, Azienda Ospedaliera Universitaria, 43126 Parma, Italy.
Ángeles FidalgoDepartment of Internal Medicine, Hospital Universitario de Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-6566-9029
Salvador OrtizDepartment of Statistics, Universidad Autónoma Madrid, 28049 Madrid, Spain.ORCID 0000-0001-8783-1920
Manuel MonrealFaculty of Health Sciences, Universidad Católica San Antonio de Murcia (UCAM), 30107 Murcia, Spain.ORCID 0000-0002-0494-0767
For The Riete Investigators
Universidad Complutense de Madrid · ESAzienda Ospedaliera Universitaria Policlinico "G. Martino" · ITBar-Ilan University · ILBrigham and Women's Hospital · USCharles University · CZComplejo Hospitalario de Salamanca · ESHospital Universitari Joan XXIII de Tarragona · ESHospital Universitario Rey Juan Carlos · ESHospital Universitario Virgen de la Arrixaca · ESInstituto de Salud Carlos III · ESMadrid Health Service · ESMedical University of Vienna · ATOspedale di Parma · ITUniversidad Católica de Murcia · ESUniversidad de Alcalá · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVenous thromboembolism (VTE)-including deep vein thrombosis, pulmonary embolism, and cerebral venous sinus thrombosis (CVST)-may occur early after vaccination against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We sought to describe the site, clinical characteristics, and outcomes of VTE after vaccination against SARS-CoV-2.

methodsIn a prospective study using the Registro Informatizado de Enfermedad TromboEmbólica (RIETE) platform, patients with VTE 4-30 days after vaccination against SARS-CoV-2 (1 February 2021 through 30 April 2021) were included. VTE patients recruited from the same centers into RIETE in the same months in 2018-2019 were selected as the reference group. All-cause mortality and major bleeding were the main study outcomes.

resultsAs of 30 April 2020, 102 patients with post-vaccination VTEs had been identified (28 after adenovirus-based vaccination [ChAdOx1 nCov-19; AstraZeneca] and 74 after mRNA-based vaccination [mRNA-1273; Moderna, and BNT162b2; Pfizer]). Compared with 911 historical controls, patients with VTE after adenovirus-based vaccination more frequently had CVST (10.7% vs. 0.4%,

conclusionsCompared with historical controls, VTE after adenovirus-based vaccination against SARS-CoV-2 is accompanied by thrombocytopenia, occurs in unusual sites, and is associated with worse clinical outcomes.

Indexed as

Registries2019-nCoV Vaccine mRNA-1273AgedAged, 80 and overBNT162 VaccineChAdOx1 nCoV-19COVID-19FemaleHumansMaleMiddle AgedOutcome Assessment, Health CareProspective StudiesRisk FactorsThrombocytopeniaTime Factors2019-nCoV Vaccine mRNA-1273BNT162 VaccineChAdOx1 nCoV-19COVID-19SARS-CoV-2vaccinationvenous thromboembolism

Identifiers

PMID35215771
PMCPMC8878689
OpenAlexW4206422764

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.