Evidence map›Paper›PMID 35215762›Full record

Observational studyViruses2022

Epstein-Barr Virus (EBV) Genotypes Associated with the Immunopathological Profile of People Living with HIV-1: Immunological Aspects of Primary EBV Infection.

Leonn Mendes Soares Pereira, Eliane Dos Santos França, Iran Barros Costa, Igor Tenório Lima, Amaury Bentes Cunha Freire, Francisco Lúzio de Paula Ramos, Talita Antonia Furtado Monteiro, Olinda Macedo, Rita Catarina Medeiros Sousa, Felipe Bonfim Freitas and 2 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Leonn Mendes Soares PereiraLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.
Eliane Dos Santos FrançaEpstein-Barr Virus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Iran Barros CostaEpstein-Barr Virus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Igor Tenório LimaEpstein-Barr Virus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Amaury Bentes Cunha FreireEpidemiology and Surveillance Service, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Francisco Lúzio de Paula RamosEpidemiology and Surveillance Service, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Talita Antonia Furtado MonteiroEpstein-Barr Virus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Olinda MacedoRetrovirus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Rita Catarina Medeiros SousaSchool of Medicine, Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.
Felipe Bonfim FreitasRetrovirus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Igor Brasil CostaEpstein-Barr Virus Laboratory, Virology Department, Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.ORCID 0000-0003-2600-4109
Antonio Carlos Rosário VallinotoLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.ORCID 0000-0003-1135-6507
Instituto Evandro Chagas · BRUniversidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of the present study was to evaluate the immunological profile of adult HIV-1 MATERIALS AND

methodsPrimary EBV infection was screened by the semiquantitative detection of IgM and IgG anti-VCA. Genotypes were determined by conventional PCR. EBV and HIV viral load (VL) were quantified by real-time PCR. Cytokine dosage and cell quantification were performed by cytometry.

resultsOnly HIV-1

conclusionsDifferent immunological profiles were associated with EBV genotypes in primary infection, with EBV-2 being more frequent in patients with low levels of HIV viral load. With late infection monitoring and consequent delay in the initiation of HAART, clinical changes and effects on the maintenance of the immune response were observed.

Indexed as

AdolescentAdultAgedAged, 80 and overCoinfectionCross-Sectional StudiesEpstein-Barr Virus InfectionsFemaleGenotypeHerpesvirus 4, HumanHIV-1HIV InfectionsHIV SeropositivityHumansImmunityMalecoinfectionEBVHIV-1immunopathological profile

Identifiers

PMID35215762
PMCPMC8880155
OpenAlexW4205158626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.